Determination of nitrofurantoin in pharmaceutical preparations using flow injection-spectrophotometry
Joint Authors
Muayyad, Marwah
Hadi, Hind Jasim
Source
Arab Journal of Basic and Applied Sciences
Issue
Vol. 24, Issue 0 (31 Oct. 2017), pp.74-80, 7 p.
Publisher
University of Bahrain College of Science
Publication Date
2017-10-31
Country of Publication
Bahrain
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Nitrofurantoin (NIT) is used as an antibiotic for the treatment of urinary tract infection.
To determine the concentration of NIT in pharmaceutical preparations, two cost-effective extraction-free flow injection (FI) spectrophotometric methods (direct and indirect) were studied.
The direct FI method was based on the reaction of NIT with potassium hydroxide and the formation of a red/orange coloured product with absorbance measured at 471 nm.
The indirect method used a reduction reaction of NIT and involved an oxidative coupling step with 3-methyl-2- benzothiazolinone hydrazone hydrochloride (MBTH).
The second method resulted in a green coloured product with absorbance measured at 610 nm.
Both direct and indirect FI methods were in agreement with Beer’s law over a concentration range of 5–300 mg/mL.
In addition, the limit for detection of the reaction product for direct and indirect method was 1.9 and 4.8 mg/mL, respectively.
FI spectrophotometric methods used in the present study can be applied for the analysis of NIT in different pharmaceutical dosage forms.
American Psychological Association (APA)
Hadi, Hind Jasim& Muayyad, Marwah. 2017. Determination of nitrofurantoin in pharmaceutical preparations using flow injection-spectrophotometry. Arab Journal of Basic and Applied Sciences،Vol. 24, no. 0, pp.74-80.
https://search.emarefa.net/detail/BIM-760678
Modern Language Association (MLA)
Hadi, Hind Jasim& Muayyad, Marwah. Determination of nitrofurantoin in pharmaceutical preparations using flow injection-spectrophotometry. Arab Journal of Basic and Applied Sciences Vol. 24 (Oct. 2017), pp.74-80.
https://search.emarefa.net/detail/BIM-760678
American Medical Association (AMA)
Hadi, Hind Jasim& Muayyad, Marwah. Determination of nitrofurantoin in pharmaceutical preparations using flow injection-spectrophotometry. Arab Journal of Basic and Applied Sciences. 2017. Vol. 24, no. 0, pp.74-80.
https://search.emarefa.net/detail/BIM-760678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 80
Record ID
BIM-760678