Lipid abnormalities in patients with chronic kidney disease : implications for the pathophysiology of atherosclerosis

Abstract EN

Objective : To evaluate the lipid abnormalities in patients with end stage renal disease who were on maintenance regular haemodialysis.

Methods : The study was conducted on 50 patients in the dialysis unit in Ibn-Sina Teaching Hospital in Mosul city, from May 2006 to October 2006, of them 26 were males and 24 were females, and a control group of 50 persons nearly matched with age, sex and body mass index.

Demographic characteristic and written concern were obtained for both groups, the diabetic and patients with end stage renal disease who are already on lipid lowering drugs were excluded.

Total cholesterol and triglyceride (TG) were determined enzymatically using spectro-photometric device.

Serum high density lipoprotein (HDL) was determined using (C-HDL Pre) kit.

The concentration of LDL and VLDL cholesterol were calculated according to the Friedewald formula.

All patient underwent electrocardiography (ECG, using ASPEL-ASCARD B5-ECO device).

The same tests were conducted for the control group.

Results : A critical decrease was observed in serum high density lipoprotein level (p<0.001) in patients when compared with healthy controls.

A significant increase in serum triglyceride content of patients (p<0.001) was also observed.

There was a significant tendency to atherosclerotic heart diseases in patients with end stage renal disease who have dyslipidemia when compared with healthy controls.

It was observed in this study, that improvements in lipid profile results were achieved with more frequent session of haemodialysis per week.

Conclusions : These abnormalities of blood lipids is probably contributing factor to the high incidence of atherosclerotic heart diseases in this population of patients.

Increasing the frequency of dialysis could be of benefit and far better outcome obtained regarding lipid profile improvement.-