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Efficacy and safety of infliximab on colonic mucosal healing in patients with moderate-to-severe ulcerative colitis
Joint Authors
Ramadan, Haidi Karam Allah
al-Attar, Madihah M.
Muhammad, Khalid F.
Hasan, Ilham Ahmad
Ismail, Ali A.
Source
Journal of Current Medical Research and Practice
Issue
Vol. 2, Issue 1 (30 Apr. 2017), pp.42-46, 5 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background Infliximab (IFX), a monoclonal anti-tumor necrosis factor-α antibody, is commonly used for the treatment of moderate-to-severe inflammatory bowel diseases.
No sufficient data are present for its role in the treatment of ulcerative colitis (UC) in our area.
We studied the efficacy and safety profile of IFX in treating patients with refractory UC.
Patients and methods This prospective study included 48 adult patients with refractory UC.
They received IFX (5 mg/kg) intravenously at weeks 0, 2, and 6 at Farwaniya Hospital, Kuwait, between 2013 and 2016.
Patients were followed-up for 12 weeks and re-evaluated for clinical and endoscopic response to therapy.
Results With the exception of four patients who were excluded from the study because of serious side-effects, 44 patients completed the study.
At week 12, clinical remission and colonic mucosal healing were achieved in 29 (65.9%) patients after initiating IFX treatment.
Of these 29 responders, no relapse occurred.
No serious adverse events or mortalities were recorded during the course of treatment among the studied patients treated with IFX.
Conclusion IFX is a safe and efficient therapy that may be useful for induction of remission in patients with refractory UC.
American Psychological Association (APA)
Muhammad, Khalid F.& Ismail, Ali A.& Hasan, Ilham Ahmad& Ramadan, Haidi Karam Allah& al-Attar, Madihah M.. 2017. Efficacy and safety of infliximab on colonic mucosal healing in patients with moderate-to-severe ulcerative colitis. Journal of Current Medical Research and Practice،Vol. 2, no. 1, pp.42-46.
https://search.emarefa.net/detail/BIM-760837
Modern Language Association (MLA)
Muhammad, Khalid F.…[et al.]. Efficacy and safety of infliximab on colonic mucosal healing in patients with moderate-to-severe ulcerative colitis. Journal of Current Medical Research and Practice Vol. 2, no. 1 (Jan. / Apr. 2017), pp.42-46.
https://search.emarefa.net/detail/BIM-760837
American Medical Association (AMA)
Muhammad, Khalid F.& Ismail, Ali A.& Hasan, Ilham Ahmad& Ramadan, Haidi Karam Allah& al-Attar, Madihah M.. Efficacy and safety of infliximab on colonic mucosal healing in patients with moderate-to-severe ulcerative colitis. Journal of Current Medical Research and Practice. 2017. Vol. 2, no. 1, pp.42-46.
https://search.emarefa.net/detail/BIM-760837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 46
Record ID
BIM-760837