NUCB 2 Nesfatin-1 : a potent meal regulatory hormone and its role in diabetes
Joint Authors
Derakhshan, Sima Mansuri
Khalili, Soodabeh
Khaniani, Mahmud Shukri
Afkhami, Fatemeh
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 18, Issue 2 (30 Apr. 2017), pp.105-109, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Nesfatin-1, a newly discovered calcium and DNA binding peptide, originate from nucleobindin 2 (NUCB2) precursors and expressed by central and peripheral nervous system, and peripheral tissues such as digestive organs and adipose tissues.
It has the astonishingly large number of chemical messengers for full appetite and introduced as a potential anorectic factor with ability to modulate body weight and probably, energy homeostasis.
Nesfatin-1/NUCB2 level in the circulation is elevated after meal intake and decreased during a fast.
Its food intake suppression effect is independent from the leptin pathway, and act via the melanocortin signaling.
On the other hand, Nesfatin-1 colocalizes with insulin in pancreatic beta islet cells and has been shown to increase insulin secretion.
Methodology: PubMed databases were searched for ‘‘NUCB2 or nesfatin-1 or nucleobindin” with the combination of ‘‘diabetes mellitus”.
Included papers were further searched manually for additional studies.
The databases were searched up to 2015.
Fifty one articles were selected for full text review.
Result: Centrally controlled Nesfatin-1 was stated to raise peripheral and hepatic insulin sensitivity by reducing gluconeogenesis and stimulating peripheral glucose uptake in vivo.
Conclusion: Nesfatin-1 has gain attention as a new target to generate, drug for treatment of endocrine nutritional and metabolic disorders like obesity and type 2 diabetes mellitus.
American Psychological Association (APA)
Khalili, Soodabeh& Khaniani, Mahmud Shukri& Afkhami, Fatemeh& Derakhshan, Sima Mansuri. 2017. NUCB 2 Nesfatin-1 : a potent meal regulatory hormone and its role in diabetes. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 2, pp.105-109.
https://search.emarefa.net/detail/BIM-760960
Modern Language Association (MLA)
Khalili, Soodabeh…[et al.]. NUCB 2 Nesfatin-1 : a potent meal regulatory hormone and its role in diabetes. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 2 (Apr. 2017), pp.105-109.
https://search.emarefa.net/detail/BIM-760960
American Medical Association (AMA)
Khalili, Soodabeh& Khaniani, Mahmud Shukri& Afkhami, Fatemeh& Derakhshan, Sima Mansuri. NUCB 2 Nesfatin-1 : a potent meal regulatory hormone and its role in diabetes. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 2, pp.105-109.
https://search.emarefa.net/detail/BIM-760960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 108-109.
Record ID
BIM-760960