The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital
Author
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 58, Issue 4 (31 Dec. 2016), pp.366-370, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
Background: Thalassemia is a form of inherited autosomal recessive blood disorder characterized by abnormal formation of hemoglobin.
Objective: Determine frequencies & association of HLA class II alleles (DRB1& DQB1) in Iraqi β-thalassemia major patients.
Patients: seventy unrelated randomly selected β-thalassemia major patients, and one hundred unrelated randomly selected healthy individuals, composed the control group.
Methods: low resolution PCR-SSO (Sequence Specific Oligonucleotide) technique was used for HLA typing.
Results: HLA DQB1*5 give significance importance as an etiological risk factor for β-thalassemia major; HLA DQB1*3 give significance importance as a preventive risk factor for β-thalassemia major.
Conclusion: The positive association of HLA DQB1*5 and DQB1*3 with β-thalassemia major may have the possibility that these antigens, or the genes encoding them, are closely linked with other possible susceptibility genes.
American Psychological Association (APA)
Zayni, Sarmad M.. 2016. The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital. Journal of the Faculty of Medicine Baghdad،Vol. 58, no. 4, pp.366-370.
https://search.emarefa.net/detail/BIM-761052
Modern Language Association (MLA)
Zayni, Sarmad M.. The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital. Journal of the Faculty of Medicine Baghdad Vol. 58, no. 4 (2016), pp.366-370.
https://search.emarefa.net/detail/BIM-761052
American Medical Association (AMA)
Zayni, Sarmad M.. The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital. Journal of the Faculty of Medicine Baghdad. 2016. Vol. 58, no. 4, pp.366-370.
https://search.emarefa.net/detail/BIM-761052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 369-370
Record ID
BIM-761052