Spectrophotometric determination of phenylephrine hydrochloride in pharmaceutical preparations
Other Title(s)
التقدير الطيفي للفنيلفرين هيدروكلوريد في عدد من المستحضرات الصيدلانية
Author
Source
Issue
Vol. 14, Issue 1 العلوم الصرفة و الهندسية (30 Jun. 2011), pp.112-118, 7 p.
Publisher
Publication Date
2011-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
A simple, rapid and sensitive spectrophotometric method for determination of phenylephrine hydrochloride (PPH) in pure form as well as dosage forms is described.
The method is based on the oxidative coupling of PPH with N,N-Diethyl-p-phenylenediamine monohydrochloride (N,N-DE-PPD) in present of N-Bromosuccinimide as oxidizing agent in sodium hydroxide medium.
Beer's law is obeyed in the concentration range of 0.5 - 16 μg ml−1 for PPH with a molar absorptivity of 11381 L.mol-1.cm-1, the accuracy is 100.38% and the relative standard deviation was less than 2.76%.
The method was successfully applied for the determination of PPH in pharmaceutical preparations and the results agree favorably with the official and reported methods.
Common excipients used as additives in pharmaceuticals do not interfere in the proposed method.
The method offers the advantages of simplicity, rapidity and sensitivity without the need for extraction or heating.
American Psychological Association (APA)
al-Isawti, Firas Muhsin. 2011. Spectrophotometric determination of phenylephrine hydrochloride in pharmaceutical preparations. Journal of Dohuk University،Vol. 14, no. 1 العلوم الصرفة و الهندسية, pp.112-118.
https://search.emarefa.net/detail/BIM-761104
Modern Language Association (MLA)
al-Isawti, Firas Muhsin. Spectrophotometric determination of phenylephrine hydrochloride in pharmaceutical preparations. Journal of Dohuk University Vol. 14, no. 1 Pure and Engineering Sciences (2011), pp.112-118.
https://search.emarefa.net/detail/BIM-761104
American Medical Association (AMA)
al-Isawti, Firas Muhsin. Spectrophotometric determination of phenylephrine hydrochloride in pharmaceutical preparations. Journal of Dohuk University. 2011. Vol. 14, no. 1 العلوم الصرفة و الهندسية, pp.112-118.
https://search.emarefa.net/detail/BIM-761104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 117-118
Record ID
BIM-761104