![](/images/graphics-bg.png)
Histopathological and immunohistochemical study of matrix metalloproteinase-2 and matrix metalloproteinase-9 in breast carcinoma
Joint Authors
Sulayman, Ahmad A.
Shabana, Marwah al-Arabi
Habib, Fahimah M.
Abbas, Najla F.
Source
Journal of the Arab Society for Medical Research
Issue
Vol. 12, Issue 1 (30 Jun. 2017), pp.6-12, 7 p.
Publisher
Arab Society for Medical Research
Publication Date
2017-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background / aim Breast cancer is the most harmful tumor among women around the world, with increasing incidence rates.
Invasion and metastasis are the most insidious and lifethreatening parts of the cancer.
Efforts have been made to understand the mechanisms that regulate and facilitate the metastatic process.
This step in metastasis of malignant cells requires the association of proteolytic catalysts that degrade protein segment of the extracellular matrix.
Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are the members of degrading enzymes required intumoradvancement, invasion,andmetastasis.Thisworkaims to examine the utility ofMMPs in breast carcinoma to assess their usefulness in growth, invasion, and metastasis.
Patients and methods A total of 60 samples of cases of breast cancer with positive and negative lymph nodes were collected randomly as paraffin blocks which was previously prepared material.
The samples from the cases were immunostained for MMP-2 and MMP-9, and their expression was correlated with various clinicopathological parameters.
Results Most cases of cancer were presented in the age group 51–60 years.
The most common type was invasive duct carcinoma Not Otherwise Specified (NOS), representing 70% of cases.
Overall, 51 (85%) cases were positive for MMP-2 whereas 54 (90%) cases were positive for MMP-9.
Presence of MMP-2 and MMP-9 in peritumoral stroma was in the ratio of 60 and 64%, respectively.
Both markers were significantly elevated in malignant tissues of patient with lymph node metastasis as compared with those without lymph node metastasis (P=0.029 and 0.048, respectively).
The expression of MMP-2 and MMP-9 increased with advanced clinical staging and grading (P=0.015 and 0.011).
Conclusion Expression of MMP-2 and MMP-9 in breast cancer is closely correlated with positive lymph node, high histological grade, and advanced clinical stage.
More studies with a huge sample size are needed to assess the prognostic role of MMPs in breast cancer.
The use of MMP inhibitors as an adjuvant treatment for breast carcinoma is recommended
American Psychological Association (APA)
Abbas, Najla F.& Shabana, Marwah al-Arabi& Habib, Fahimah M.& Sulayman, Ahmad A.. 2017. Histopathological and immunohistochemical study of matrix metalloproteinase-2 and matrix metalloproteinase-9 in breast carcinoma. Journal of the Arab Society for Medical Research،Vol. 12, no. 1, pp.6-12.
https://search.emarefa.net/detail/BIM-761288
Modern Language Association (MLA)
Abbas, Najla F.…[et al.]. Histopathological and immunohistochemical study of matrix metalloproteinase-2 and matrix metalloproteinase-9 in breast carcinoma. Journal of the Arab Society for Medical Research Vol. 12, no. 1 (Jan. / Jun. 2017), pp.6-12.
https://search.emarefa.net/detail/BIM-761288
American Medical Association (AMA)
Abbas, Najla F.& Shabana, Marwah al-Arabi& Habib, Fahimah M.& Sulayman, Ahmad A.. Histopathological and immunohistochemical study of matrix metalloproteinase-2 and matrix metalloproteinase-9 in breast carcinoma. Journal of the Arab Society for Medical Research. 2017. Vol. 12, no. 1, pp.6-12.
https://search.emarefa.net/detail/BIM-761288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 12
Record ID
BIM-761288