Drug interaction of using lincomycin hcl and diclazuril alone or together in controlling cecal coccidiosis in chickens

Abstract EN

This study was carried out to test the interaction between lincomycin and diclazuril and its effect on experimentally infected chickens with E.tenella in order to evaluate any interference of lincomycin upon anticoccdeal efficacy of diclazuril and evaluate their efficacy on improving oocyst counting, hematological and biochemical parameters.

It was observed that administration of diclazuril has potent anticoccideal efficacy with therapeutic recommended dose at (2.5 ppm) given after the symptoms had appeared (on 5th day of infection) for 3 successive days in drinking water.

On the other hand lincomycin has a very weak anticoccideal efficacy at dose (30mg/kg.b.wt.) given after the symptoms of infection had appeared (on 5th day of infection) for 3 successive days in drinking water and didn't gave satisfactory benefits after the symptoms had appeared.

Additionally, The use of lincomycin and diclazuril together did not show any antagonist interaction between them but had compatibilities between each other and that appeared in improving oocyst counting,, improved biochemical and hematological parameters