Addition of 3-day aprepitant to ondansetron and dexamethasone for prophylaxis of chemotherapy-induced nausea and vomiting among patients with diffuse large B cell lymphoma receiving 5-day cisplatin-based chemotherapy
Joint Authors
Abd al-Malak, Rafat
Abbas, Nuha
Shohdy, Kyrillus S.
Fawzi, Radwa
Salim, Dalal S.
Ismail, Muhammad
Safwat, Izzat
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 29, Issue 3 (30 Sep. 2017), pp.155-158, 4 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2017-09-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background : Neurokinin-1 receptor antagonists, such as aprepitant are currently emerging as powerful prophylactic agents for chemotherapy-induced nausea and vomiting (CINV).
Therefore, it is important to adjust the anti-emetic regimens based on personal risk factors of the patient, duration of the chemotherapy regimen and cost-effectiveness.
Purpose : To determine the efficacy of the 3-day aprepitant along with ondansetron and dexamethasone in controlling CINV in patients with large B cell lymphoma receiving multiday-cisplatin regimen chemotherapy.
Methods : This is a pilot prospective cross-over trial.
Patients were allocated to either aprepitant 125 mg on day 1 and 80 mg on days 2 & 3 or placebo in the first 2 cycles, with crossover to the opposite treatment in the 3rd and 4th cycles.
The primary end point was complete response (CR) of both acute (days 1–5) and delayed (days 6–8) CINV.
CR means neither to develop emetic episodes nor to use rescue anti-emetics medication.
Results : Twelve of the 15 patients recruited for the study were fully evaluable and completed 4 cycles of ESHAP regimen with a total of 48 cycles given.
In the cycles with aprepitant and those without the CR were 83.3 % and 0% respectively (p < 0.05).
Patients receiving aprepitant in the first 2 cycles recorded less nausea in subsequent cycles that were given without aprepitant.
This was not statistically significant.
Conclusion : This triple anti-emetic regimen showed efficacy in controlling the multi-day cisplatininduced nausea and vomiting.
Further randomized controlled trials are needed to compare between 3- day and 7-day aprepitant for multi-day cisplatin regimens.
American Psychological Association (APA)
Abd al-Malak, Rafat& Abbas, Nuha& Shohdy, Kyrillus S.& Ismail, Muhammad& Fawzi, Radwa& Salim, Dalal S.…[et al.]. 2017. Addition of 3-day aprepitant to ondansetron and dexamethasone for prophylaxis of chemotherapy-induced nausea and vomiting among patients with diffuse large B cell lymphoma receiving 5-day cisplatin-based chemotherapy. Journal of the Egyptian National Cancer Institute،Vol. 29, no. 3, pp.155-158.
https://search.emarefa.net/detail/BIM-761404
Modern Language Association (MLA)
Abd al-Malak, Rafat…[et al.]. Addition of 3-day aprepitant to ondansetron and dexamethasone for prophylaxis of chemotherapy-induced nausea and vomiting among patients with diffuse large B cell lymphoma receiving 5-day cisplatin-based chemotherapy. Journal of the Egyptian National Cancer Institute Vol. 29, no. 3 (Sep. 2017), pp.155-158.
https://search.emarefa.net/detail/BIM-761404
American Medical Association (AMA)
Abd al-Malak, Rafat& Abbas, Nuha& Shohdy, Kyrillus S.& Ismail, Muhammad& Fawzi, Radwa& Salim, Dalal S.…[et al.]. Addition of 3-day aprepitant to ondansetron and dexamethasone for prophylaxis of chemotherapy-induced nausea and vomiting among patients with diffuse large B cell lymphoma receiving 5-day cisplatin-based chemotherapy. Journal of the Egyptian National Cancer Institute. 2017. Vol. 29, no. 3, pp.155-158.
https://search.emarefa.net/detail/BIM-761404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 157-158
Record ID
BIM-761404