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Intraoperative magnesium infusion as an adjuvant to a bilateral single-injection thoracic paravertebral block for laparoscopic cholecystectomy
Author
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 5, Issue 3 (30 Sep. 2012), pp.321-326, 6 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2012-09-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background Magnesium has antinociceptive effects.
This prospective randomized, double-blinded, controlled study was designed to examine whether an intraoperative administration of intravenous magnesium with a bilateral thoracic paravertebral block (PVB) enhances postoperative analgesia while reducing opioid consumption and opioid-related side effects.
Methods Fifty-nine patients undergoing laparoscopic cholecystectomy were administered a bilateral single-injection PVB at the level of T5 with 25 ml bupivacaine 0.5% before induction of general anesthesia.
Patients were assigned to two groups.
Group M (magnesium group) received a loading dose of magnesium sulphate 30 mg/kg in 100 ml of normal saline over 10 min, followed by an infusion of 10 mg/kg/h till the end of surgery.
The control group (group C) received the same volume of normal saline as a loading dose, followed by a continuous infusion.
In both groups, postoperative pain was initially controlled by intravenous fentanyl titration and then fentanyl patient-controlled analgesia.
Cumulative and patient-controlled analgesia fentanyl consumption, pain intensities, sedation scores, cardiovascular and respiratory variables and opioid-related adverse effects were recorded for 36 h after the operation.
Results Compared with the control group, patients in the magnesium group required 23.6% less fentanyl during the first 36 h postoperatively, with significantly better visual analogue scale scores, less incidence of pruritis (6 vs.
15 patients, respectively; P= 0.0376) and longer time to first analgesic request [413 (56) min vs.
247 (46) min; Po0.001].
Fewer patients in group M experienced nausea and vomiting than those in group C (7 vs.
18 patients, respectively; P= 0.0116).
Conclusion A continuous intravenous magnesium infusion may be a useful adjuvant to PVB for patients undergoing laparoscopic cholecystectomy
American Psychological Association (APA)
Abd al-Majid, Walid M.. 2012. Intraoperative magnesium infusion as an adjuvant to a bilateral single-injection thoracic paravertebral block for laparoscopic cholecystectomy. Ain Shams Journal of Anesthesiology،Vol. 5, no. 3, pp.321-326.
https://search.emarefa.net/detail/BIM-761551
Modern Language Association (MLA)
Abd al-Majid, Walid M.. Intraoperative magnesium infusion as an adjuvant to a bilateral single-injection thoracic paravertebral block for laparoscopic cholecystectomy. Ain Shams Journal of Anesthesiology Vol. 5, no. 3 (Sep. 2012), pp.321-326.
https://search.emarefa.net/detail/BIM-761551
American Medical Association (AMA)
Abd al-Majid, Walid M.. Intraoperative magnesium infusion as an adjuvant to a bilateral single-injection thoracic paravertebral block for laparoscopic cholecystectomy. Ain Shams Journal of Anesthesiology. 2012. Vol. 5, no. 3, pp.321-326.
https://search.emarefa.net/detail/BIM-761551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 326
Record ID
BIM-761551