Radiochemical and biological characteristics of 125i-diclofenac for inflammation sites detection
Joint Authors
Abd al-Halim, S. M.
Abd al-Bari, A.
Sad, A.
Amin, A. M.
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 50, Issue 4 (30 Oct. 2017), pp.114-121, 8 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2017-10-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
The aim of this work was to develop a potential selective radiopharmaceutical agent for the inflammation imaging to monitor the treatment process.
Diclofenac was successfully labeled with 125I.
This labeling reaction was carried out via electrophilic substitution of hydrogen atom with the iodonium ion I+.
The reaction was found to be strongly dependent on the pH of the reaction medium.
At pH 7, the labeling yield was maximum.
This may be due to the good solubility of diclofenac, good protonation and good working of the oxidizing agent at this pH value.
The labeling reaction was very fast but required 15 min for completion.
The produced 125I-diclofenac was found stable in–vivo as the thyroid gland uptake did not exceed 0.4 %.
Labeled diclofenac showed a good localization in sterile inflamed muscle with T/NT value 9.1 at 4 h post injection.
It excreted mainly via the kidney.
The imaging must be carried out before 8-hour post injection.
American Psychological Association (APA)
Sad, A.& Amin, A. M.& Abd al-Halim, S. M.& Abd al-Bari, A.. 2017. Radiochemical and biological characteristics of 125i-diclofenac for inflammation sites detection. Arab Journal of Nuclear Sciences and Applications،Vol. 50, no. 4, pp.114-121.
https://search.emarefa.net/detail/BIM-761607
Modern Language Association (MLA)
Abd al-Halim, S. M.…[et al.]. Radiochemical and biological characteristics of 125i-diclofenac for inflammation sites detection. Arab Journal of Nuclear Sciences and Applications Vol. 50, no. 4 (Oct. 2017), pp.114-121.
https://search.emarefa.net/detail/BIM-761607
American Medical Association (AMA)
Sad, A.& Amin, A. M.& Abd al-Halim, S. M.& Abd al-Bari, A.. Radiochemical and biological characteristics of 125i-diclofenac for inflammation sites detection. Arab Journal of Nuclear Sciences and Applications. 2017. Vol. 50, no. 4, pp.114-121.
https://search.emarefa.net/detail/BIM-761607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 121
Record ID
BIM-761607