Establishment of preliminary regulatory network of TRPV1 and related cytokines
Joint Authors
Zhou, Zheng
Jin, Wenwen
Ren, Yafeng
Chen, Chuanliang
Zhang, Jianhua
Zhang, Ning
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 3 (31 Mar. 2017), pp.582-588, 7 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Our purpose was to investigate the regulatory mechanism of TRPV1 and related cytokines on children bronchial asthma.
TRPV1 mRNA level and two SNP genotypes of children in case group and control group were detected by real-time quantitative PCR.
Western blot and ELISA were used to measure the levels of cytokines like IgE, IL-2, etc.
Their correlations were analyzed by Logistic regression and KEGG analysis.
Moreover, tertiary structure of protein and miRNA binding sites were also predicted by online tools.
Case group was obviously different from control group in TRPV1 mRNA level, the two SNP genotypes distribution and the related cytokines levels.
Logistic regression analysis further demonstrated that TRPV1 mRNA level, EOS, IL-4 and IL-5 may be risk factors for children bronchial asthma.
And based on that, the preliminary regulatory network of children bronchial asthma was drawn.
What’s more, mutation of rs4790521 and rs4790522 in TRPV1 gene both induced its corresponding miRNA binding site’s change.
The preliminary regulatory network of TRPV1 and related cytokines on children bronchial asthma established in this study provides certain theoretical basis for pathogenesis and treatment of children bronchial asthma.
American Psychological Association (APA)
Zhang, Jianhua& Zhou, Zheng& Zhang, Ning& Jin, Wenwen& Ren, Yafeng& Chen, Chuanliang. 2017. Establishment of preliminary regulatory network of TRPV1 and related cytokines. Saudi Journal of Biological Sciences،Vol. 24, no. 3, pp.582-588.
https://search.emarefa.net/detail/BIM-761768
Modern Language Association (MLA)
Zhang, Jianhua…[et al.]. Establishment of preliminary regulatory network of TRPV1 and related cytokines. Saudi Journal of Biological Sciences Vol. 24, no. 3 (Mar. 2017), pp.582-588.
https://search.emarefa.net/detail/BIM-761768
American Medical Association (AMA)
Zhang, Jianhua& Zhou, Zheng& Zhang, Ning& Jin, Wenwen& Ren, Yafeng& Chen, Chuanliang. Establishment of preliminary regulatory network of TRPV1 and related cytokines. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 3, pp.582-588.
https://search.emarefa.net/detail/BIM-761768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 587-588
Record ID
BIM-761768