Study on specificity of colon carcinoma-associated serum markers and establishment of SVM prediction model
Joint Authors
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 3 (31 Mar. 2017), pp.644-648, 5 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
We aimed to evaluate the specificity of 12 tumor markers related to colon carcinoma and identify the most sensitive index.
Logistic regression and Bhattacharyya distance were used to evaluate the index.
Then, different index combinations were used to establish a support vector machine (SVM) diagnosis model of malignant colon carcinoma.
The accuracy of the model was checked.
High accuracy was assumed to indicate the high specificity of the index.
Through Logistic regression, three indexes, CEA, HSP60 and CA199, were screened out.
Using Bhattacharyya distance, four indexes with the largest Bhattacharyya distance were screened out, including CEA, NSE, AFP, and CA724.
The specificity of the combination of the above six indexes was higher than that of other combinations, so did the accuracy of the established SVM identification model.
Using Logistic regression and Bhattacharyya distance for detection and establishing an SVM model based on different serum marker combinations can increase diagnostic accuracy, providing a theoretical basis for application of mathematical models in cancer diagnosis.
American Psychological Association (APA)
Li, Lu& Ma, Xuhui. 2017. Study on specificity of colon carcinoma-associated serum markers and establishment of SVM prediction model. Saudi Journal of Biological Sciences،Vol. 24, no. 3, pp.644-648.
https://search.emarefa.net/detail/BIM-761774
Modern Language Association (MLA)
Li, Lu& Ma, Xuhui. Study on specificity of colon carcinoma-associated serum markers and establishment of SVM prediction model. Saudi Journal of Biological Sciences Vol. 24, no. 3 (Mar. 2017), pp.644-648.
https://search.emarefa.net/detail/BIM-761774
American Medical Association (AMA)
Li, Lu& Ma, Xuhui. Study on specificity of colon carcinoma-associated serum markers and establishment of SVM prediction model. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 3, pp.644-648.
https://search.emarefa.net/detail/BIM-761774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 647-648
Record ID
BIM-761774