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Effect of sophora japonica total flavonoids on pancreas, kidney tissue morphology of streptozotocin-induced diabetic mice model
Joint Authors
Wang, Ting
Li, Min
Li, Yan
Miao, Mingsan
Li, Cairong
Xu, Yuyin
Bai, Ming
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 3 (31 Mar. 2017), pp.741-747, 7 p.
Publisher
Publication Date
2017-03-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
- Physiological effects
- Anatomy
- Pancreas
- Diabetic nephropathies
- Flavonoids
- Streptozotocin
- Styphnolobium japonicum
Abstract EN
To observe effect of sophora japonica total flavonoids on pancreas, kidney tissue morphology of streptozotocin-induced diabetic mice model.
Mice received tail vein injection of streptozotocin (60 mg/kg) for diabetes modeling.
The model mice were divided into five groups, to be respectively fed with high, middle and small doses of sophora japonica total flavonoids solution, metformin solution and saline of the same volume.
Another blank control group was set to be fed with saline of the same volume.
The mice were administered once a day for 30 consecutive days, to be euthanatized after fasting blood glucose level testing on 30th day with pancreas, kidney taken out for pathological section and microscopic examination.
The mice chain streptozotocin diabetes modeling was successful, with significant pathological changes (P < 0.01) in pancreas, kidney.
Compared with model group, high, middle and small doses of sophora japonica total flavonoids could significantly alleviate streptozotocin-induced pancreas, kidney damage (P <0.01).
Conclusion: Sophora japonica total flavonoids can effectively alleviate pancreas, kidney injury of streptozotocin-induced diabetic mice model.
American Psychological Association (APA)
Wang, Ting& Miao, Mingsan& Bai, Ming& Li, Yan& Li, Min& Li, Cairong…[et al.]. 2017. Effect of sophora japonica total flavonoids on pancreas, kidney tissue morphology of streptozotocin-induced diabetic mice model. Saudi Journal of Biological Sciences،Vol. 24, no. 3, pp.741-747.
https://search.emarefa.net/detail/BIM-761810
Modern Language Association (MLA)
Wang, Ting…[et al.]. Effect of sophora japonica total flavonoids on pancreas, kidney tissue morphology of streptozotocin-induced diabetic mice model. Saudi Journal of Biological Sciences Vol. 24, no. 3 (Mar. 2017), pp.741-747.
https://search.emarefa.net/detail/BIM-761810
American Medical Association (AMA)
Wang, Ting& Miao, Mingsan& Bai, Ming& Li, Yan& Li, Min& Li, Cairong…[et al.]. Effect of sophora japonica total flavonoids on pancreas, kidney tissue morphology of streptozotocin-induced diabetic mice model. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 3, pp.741-747.
https://search.emarefa.net/detail/BIM-761810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 747
Record ID
BIM-761810