Update on pathogenesis, management, and treatment of hypertension in autosomal dominant polycystic kidney disease
Joint Authors
al-Ruwai, Fadil
Abd al-Rahim, Izz al-Din
Khidr, Adil
Hilal, Imad
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 2 (30 Apr. 2017), pp.253-260, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-04-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Hypertension is a common early finding in autosomal dominant polycystic kidney disease (ADPKD).
Improvements in screening and diagnosis of ADPKD have allowed earlier diagnosis, later onset of end-stage renal disease, and better survival.
However, the main and most effective therapy remains control of hypertension.
Hypertension is the most important modifiable risk factor in ADPKD.
Therefore, early management of hypertension reduces the incidence of cardiovascular events in ADPKD patients.
Stimulation of the renin–angiotensin–aldosterone system (RAAS) plays a central role in the pathogenesis of hypertension in ADPKD.
Therapies that block the RAAS have improved patient management, blood pressure control, and ADPKD patient survival.
This review highlights the current understanding of the epidemiology, potential pathogenetic mechanisms and proposes a strategy for the treatment and management of hypertension in ADPKD.
American Psychological Association (APA)
Hilal, Imad& al-Ruwai, Fadil& Abd al-Rahim, Izz al-Din& Khidr, Adil. 2017. Update on pathogenesis, management, and treatment of hypertension in autosomal dominant polycystic kidney disease. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 2, pp.253-260.
https://search.emarefa.net/detail/BIM-761835
Modern Language Association (MLA)
Hilal, Imad…[et al.]. Update on pathogenesis, management, and treatment of hypertension in autosomal dominant polycystic kidney disease. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 2 (Mar. / Apr. 2017), pp.253-260.
https://search.emarefa.net/detail/BIM-761835
American Medical Association (AMA)
Hilal, Imad& al-Ruwai, Fadil& Abd al-Rahim, Izz al-Din& Khidr, Adil. Update on pathogenesis, management, and treatment of hypertension in autosomal dominant polycystic kidney disease. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 2, pp.253-260.
https://search.emarefa.net/detail/BIM-761835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 257-260
Record ID
BIM-761835