Protective effects of selenium and or melatonin against cadmium chloride induced chromosomal aberrations in Swiss albino mice mus musculus BALB c
Joint Authors
Sufi, Jamal S.
al-Attar, Mustafa S. Mustafa
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 28, Issue 4 (31 Aug. 2016), pp.82-89, 8 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2016-08-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
The present study was aimed to investigate the protective role of selenium and melatonin with concentration (0.2 mg /kg b.wt./day) for selenium and (2.5 mg/kg b.
wt./day) for melatonin.
The doses were administered for five weeks five day per week against the genotoxic effect of orally given Cadmium chloride (1mg/kg b.wt.
/day) to male albino mice for five weeks (five day per week).
Thirty five male albino mice were divided into seven groups; each group contained five mice.
Chromosomal studies in bone marrow cells were used as parameters in this evaluation.
It was observed that the administration of Cadmium chloride generally produced more chromosomal aberrations such as (gap, break, ring, dicentric, centric fusion, end to end association, aneuploidy and polyploidy) compared with control.
Chromosomal aberrations were reduced in treatment with the antioxidants (Selenium, melatonin) and their combinations .Finally, it was concluded that selenium and melatonin can serve as possible anti-genotoxic agent against the clastogenic effect of Cadmium chloride.
American Psychological Association (APA)
al-Attar, Mustafa S. Mustafa& Sufi, Jamal S.. 2016. Protective effects of selenium and or melatonin against cadmium chloride induced chromosomal aberrations in Swiss albino mice mus musculus BALB c. ZANCO Journal of Pure and Applied Sciences،Vol. 28, no. 4, pp.82-89.
https://search.emarefa.net/detail/BIM-762114
Modern Language Association (MLA)
al-Attar, Mustafa S. Mustafa& Sufi, Jamal S.. Protective effects of selenium and or melatonin against cadmium chloride induced chromosomal aberrations in Swiss albino mice mus musculus BALB c. ZANCO Journal of Pure and Applied Sciences Vol. 28, no. 4 (2016), pp.82-89.
https://search.emarefa.net/detail/BIM-762114
American Medical Association (AMA)
al-Attar, Mustafa S. Mustafa& Sufi, Jamal S.. Protective effects of selenium and or melatonin against cadmium chloride induced chromosomal aberrations in Swiss albino mice mus musculus BALB c. ZANCO Journal of Pure and Applied Sciences. 2016. Vol. 28, no. 4, pp.82-89.
https://search.emarefa.net/detail/BIM-762114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 87-89
Record ID
BIM-762114