P53 immunohistochemistry in chronic periodontitis, relation to smoking and histopathologic parameters
Other Title(s)
الإظهار الكيميائي النسيجي المناعي ل P53 في التهاب ما حول الأسنان وعلاقته بالتدخين و مؤشرات نسيجية مرضية
Joint Authors
Sulayman, Shinar M.
Khalil, Amirah K.
Source
Issue
Vol. 8, Issue 2 (31 Dec. 2014), pp.57-77, 21 p.
Publisher
University of Duhok College of Medicine
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
21
Main Subjects
Abstract EN
Background and objectives Smoking is one of the main and important risk factors that increase risk of oral health problems.
There is a dose-response relationship between number of cigarettes smoked and the development of periodontal diseases, in addition, to an elevation of p53 in oral mucosa of smokers.
The aim of the study was to examine p53 immune expression in the gingival tissue samples in patients with different severity of chronic periodontitis in relation to different histopathological parameters and smoking status.
Methods Gingival tissue biopsies were taken from (30) smokers and (30) nonsmoker subjects with different severity of chronic periodontitis.
Staining profiles were classified according to the number of positive cells as well as to the location of the positive cells in the different epithelial layers of the specimens.
Results No significant difference was found between the median p53 labeling indices and any of the smoking status, severity of chronic periodontitis, epithelial thickness and number of blood vessels in the connective tissue.
However, a significant association was found between p53 immunostaining and number of inflammatory cells.
Conclusions Chronic periodontitis may accelerate smoking effects on p53 gene mutation.
American Psychological Association (APA)
Sulayman, Shinar M.& Khalil, Amirah K.. 2014. P53 immunohistochemistry in chronic periodontitis, relation to smoking and histopathologic parameters. Duhok Medical Journal،Vol. 8, no. 2, pp.57-77.
https://search.emarefa.net/detail/BIM-763662
Modern Language Association (MLA)
Sulayman, Shinar M.& Khalil, Amirah K.. P53 immunohistochemistry in chronic periodontitis, relation to smoking and histopathologic parameters. Duhok Medical Journal Vol. 8, no. 2 (Dec. 2014), pp.57-77.
https://search.emarefa.net/detail/BIM-763662
American Medical Association (AMA)
Sulayman, Shinar M.& Khalil, Amirah K.. P53 immunohistochemistry in chronic periodontitis, relation to smoking and histopathologic parameters. Duhok Medical Journal. 2014. Vol. 8, no. 2, pp.57-77.
https://search.emarefa.net/detail/BIM-763662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 74-75
Record ID
BIM-763662