Vitamin d status and metabolic abnormality profile among siblings of patients with type 2 diabetes mellitus

Abstract EN

Background: Cross-sectional data provide some evidence that circulating 25- hydroxyvitamin D is inversely associated with metabolic syndrome components.

Reported data in populations at high risk for type 2 diabetes mellitus (T2DM), however, are contradictory.

In this study we measured 25-hydroxyvitamin D [25(OH) D], glucose, triglycerides, HDL-cholesterol and insulin in siblings of patients with T2DM.

Methods: Body weight, height, waist circumference, blood pressure, glucose, insulin, triglycerides, HDL-cholesterol, and 25(OH) D were measured in 184 apparently healthy individuals, siblings of patients with T2 DM, with age range 20-40 years.

Study participants were categorized into 2 groups: a metabolically obese, normal weight (MONW) group and non-MONW group.

The association between components of metabolic syndrome and serum 25(OH) D levels was examined.

Results: Participants categorized as MONW group were 155(84.2%) ,exhibited lower serum 25(OH) D levels than did the non-MONW (p<0.01).

Significantly higher prevalence of vitamin D insufficiency (36.1% vs.

20.7%, p<0.05) and severe deficiency (8.4% vs.

3.5%, p<0.05) were found in MONW compared to non-MONW group.

MONW group had higher mean age, body mass index and waist circumference than non-MONW group.

MONW had also higher mean values for HMOA-IR, triglycerides, but lower HDL-cholesterol concentrations.

In MONW group, negative correlations of 25(OH) D were observed with waist circumference and triglycerides (p<0.001 and P<0.01, respectively) and a positive correlation was observed with HDL-cholesterol (p=0.015) Conclusion: Our data showed a low vitamin D status among siblings of T2DM patients, particularly among MONW individuals, suggested that siblings of T2DM are at increased risk of future metabolic disease.