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A one pot, three component synthesis of coumarin hybrid thiosemicarbazone derivatives and their antimicrobial evolution
Joint Authors
Vekariya, Rajesh H.
Patel, Kinjal D.
Rajani, Dhanji P.
Rajani, Smita D.
Patel, Hitesh D.
Source
Arab Journal of Basic and Applied Sciences
Issue
Vol. 23, Issue 0 (30 Jun. 2017), pp.10-19, 10 p.
Publisher
University of Bahrain College of Science
Publication Date
2017-06-30
Country of Publication
Bahrain
No. of Pages
10
Main Subjects
Topics
Abstract EN
A convenient, one-pot, multi-component protocol for the preparation of 2-(1-(2-oxo-2Hchromen- 3-yl)ethylidene)hydrazinecarbothioamide derivatives has been achieved.
Here, firstly we have reported the synthesis of 3-acetyl-2H-chromen-2-one using starch sulfuric acid and cellulose sulfuric acid as biodegradable catalysts.
Subsequently, we also carried out the reaction of isothiocynates, hydrazine hydrate and 3-acetyl-2H-chromen-2-one in the presence of catalytic amount of glacial acetic acid in refluxing ethanol to afford corresponding 2-(1-(2-oxo-2H-chromen-3-yl)ethyli dene)hydrazinecarbothioamide derivatives in high to excellent yields.
All synthesized compounds were screened for antimicrobial activity.
All compounds were found to show good to excellent activity against Escherichia coli MTCC 443.
American Psychological Association (APA)
Vekariya, Rajesh H.& Patel, Kinjal D.& Rajani, Dhanji P.& Rajani, Smita D.& Patel, Hitesh D.. 2017. A one pot, three component synthesis of coumarin hybrid thiosemicarbazone derivatives and their antimicrobial evolution. Arab Journal of Basic and Applied Sciences،Vol. 23, no. 0, pp.10-19.
https://search.emarefa.net/detail/BIM-766172
Modern Language Association (MLA)
Vekariya, Rajesh H.…[et al.]. A one pot, three component synthesis of coumarin hybrid thiosemicarbazone derivatives and their antimicrobial evolution. Arab Journal of Basic and Applied Sciences Vol. 23 (Jun. 2017), pp.10-19.
https://search.emarefa.net/detail/BIM-766172
American Medical Association (AMA)
Vekariya, Rajesh H.& Patel, Kinjal D.& Rajani, Dhanji P.& Rajani, Smita D.& Patel, Hitesh D.. A one pot, three component synthesis of coumarin hybrid thiosemicarbazone derivatives and their antimicrobial evolution. Arab Journal of Basic and Applied Sciences. 2017. Vol. 23, no. 0, pp.10-19.
https://search.emarefa.net/detail/BIM-766172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 18-19
Record ID
BIM-766172