Fish-oil supplementation and maternal mental health : a triple-blind, randomized controlled trial
Joint Authors
Ostadrahimi, Ali Rida
Muhammadi, Fatimah
Farshbaf Khalili, Azizah
Muhammad Ali Zadih, Sukaynah
Farshbaf Khalili, Ahad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 1 (31 Jan. 2017), pp.1-9, 9 p.
Publisher
Publication Date
2017-01-31
Country of Publication
United Arab Emirates
No. of Pages
9
Main Subjects
Abstract EN
Objectives: The aim of this study was to evaluate the effect of fish oil supplementation on antenatal and postpartum depression score.
Methods: This was a randomized, triple-blind, placebo-controlled trial.
We enrolled 150 eligible pregnant women with Edinburgh postnatal depression scale (EPDS) score of less than 20, aged 18 to 35 from Feburary 2014 to April 2015 in Tabriz, Iran.
Participants were randomly assigned to receive either 1000 mg of fish oil supplements or placebo from 16 - 20 weeks of gestation to one month after giving birth.
Participants completed the EPDS at baseline, 26 - 30 weeks, 35 - 37 weeks, and 30 - 45 days after birth.
Primary outcome measures were the mean depression score at 26 - 30 weeks, 35-37 weeks, and postpartum period.
The statistical analysis was intent-to-treat.
Results: A total of 150 females were included, and no one was lost to follow up.
There were significant differences between the two groups in the mean score of depression only at 35 - 37 (adjusted mean difference = -1.4; [95% CI -2.6 to -0.25]).
The mean score of depression during pregnancy and postpartum period significantly decreased within the fish oil group (P < 0.05).
There were no significant differences between the two groups in terms of the baseline docosahexaenoic acid (DHA) and eicosapentaneoic acid (EPA) serum levels.
Conclusions: Fish oil supplements significantly decreased the mean score of EPDS at weeks 35 to 37.
It seems that females may benefit from daily fish oil supplements during pregnancy especially in countries with low intake of fish yet further studies are needed to confirm these results.
American Psychological Association (APA)
Farshbaf Khalili, Azizah& Muhammad Ali Zadih, Sukaynah& Farshbaf Khalili, Ahad& Muhammadi, Fatimah& Ostadrahimi, Ali Rida. 2017. Fish-oil supplementation and maternal mental health : a triple-blind, randomized controlled trial. Iranian Red Crescent Medical Journal،Vol. 19, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-766373
Modern Language Association (MLA)
Farshbaf Khalili, Azizah…[et al.]. Fish-oil supplementation and maternal mental health : a triple-blind, randomized controlled trial. Iranian Red Crescent Medical Journal Vol. 19, no. 1 (Jan. 2017), pp.1-9.
https://search.emarefa.net/detail/BIM-766373
American Medical Association (AMA)
Farshbaf Khalili, Azizah& Muhammad Ali Zadih, Sukaynah& Farshbaf Khalili, Ahad& Muhammadi, Fatimah& Ostadrahimi, Ali Rida. Fish-oil supplementation and maternal mental health : a triple-blind, randomized controlled trial. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 1, pp.1-9.
https://search.emarefa.net/detail/BIM-766373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-9
Record ID
BIM-766373