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Is serum lactate level a prognostic factor for the incidence and mortality of ventilator- associated pneumonia among poisoned ICU-admitted patients ?
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 1 (31 Jan. 2017), pp.1-6, 6 p.
Publisher
Publication Date
2017-01-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Abstract EN
Background: Lactate level is known to increase among the majority of patients with toxicity.
This study aimed to determine whether lactate level upon admission is higher among patients with ventilator-associated pneumonia (VAP).
Objectives: We aimed to determine whether serum lactate level is associated with the increased risk of VAP in intensive care unit (ICU)-admitted patients with toxicity.
Methods: This retrospective study was conducted in a training medical poisoning center in Iran, using convenience sampling.
A total of 157 poisoned patients, aged 13 years, whowere admitted to the ICU over the past seven months, were included in the study.
Subjects were categorized into two groups, based on their VAP diagnosis (VAP-positive and non-VAP) and the outcomes (surviving or non-surviving).
The VAP-positive patients were compared with others with regard to the mean level of serum lactate level upon admission.
Additionally, non-surviving patients were compared with their surviving counterparts.
Results: Overall, 71 (45.2 %) VAS-positive cases were reported, in addition to 36 cases of mortality.
Alkaline phosphatase (ALP) was the most common toxic agent (36%), followed by methanol.
Significant differences were noted between the groups in terms of Simplified Acute Physiology Score-II (SAPS-II), Glasgow Coma Scale (GCS) score, length of ICU stay, and percentage of ventilation process.
The mean levels of lactate at admission were 3.713.35 and 4.194.09 among VAP-positive and non-VAP patients, respectively; the difference was not statistically significant.
Also, non-surviving patients had a longer ICU stay (12.20 days), compared to surviving patients (5.39) (P = 0.008).
Moreover, admission lactate level was 7.065.29 mmol/L among non-surviving patients and 3.012.53 among surviving cases (P < 0.001).
Conclusions: Based on the findings, the mortality rate was 22.9% among poisoned patients with an elevated serum lactate level.We can conclude that mortality is associated with toxicants, but not the occurrence of VAP; in fact, VAP scenarios do not elevate serum lactate level.
American Psychological Association (APA)
Muzaffari, Nasir& Mortazavi, Hilya Sadat& Alinia, Tahereh& Barari, Bahjat& Talaie, Haleh. 2017. Is serum lactate level a prognostic factor for the incidence and mortality of ventilator- associated pneumonia among poisoned ICU-admitted patients ?. Iranian Red Crescent Medical Journal،Vol. 19, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-766380
Modern Language Association (MLA)
Alinia, Tahereh…[et al.]. Is serum lactate level a prognostic factor for the incidence and mortality of ventilator- associated pneumonia among poisoned ICU-admitted patients ?. Iranian Red Crescent Medical Journal Vol. 19, no. 1 (Jan. 2017), pp.1-6.
https://search.emarefa.net/detail/BIM-766380
American Medical Association (AMA)
Muzaffari, Nasir& Mortazavi, Hilya Sadat& Alinia, Tahereh& Barari, Bahjat& Talaie, Haleh. Is serum lactate level a prognostic factor for the incidence and mortality of ventilator- associated pneumonia among poisoned ICU-admitted patients ?. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-766380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-766380