Non-muscle myosin heavy chain 9 gene (MYH9) Polymorphism (rs4821481) is associated with urinary albumin excretion in Iranian diabetic patients
Joint Authors
Qorbani, Mustafa
Asdadollahpour, Effat
Daneshpourm, Maryam
Khayat, Bahareh Sedaghati
Hashemiaghdam, Arsalan
Amoli, Mahsa Muhammad
Razi, Faridah
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 1 (31 Jan. 2017), pp.1-6, 6 p.
Publisher
Publication Date
2017-01-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Abstract EN
Background: Myosin heavy chain 9 (MYH9) gene polymorphisms have been implicated in different types of renal disease, as well as in nephropathy attributed to type 2 diabetes mellitus.
Objectives: This study sought to analyze the association of MYH9 gene polymorphism (rs4821481) with diabetic nephropathy (DN), urine albumin excretion value, and glomerular filtration rate (GFR) in an Iranian diabetic population.
Methods: This case-control study included 201 diabetic patients with and without DN, who were referred to the diabetes and metabolic center, Tehran, Iran.
The allele and genotype frequencies of rs4821481 were determined using ARMS-polymerase chain reaction (ARMS-PCR).
In both groups, blood levels of fasting glucose, HbA1c, urea, creatinine, uric acid, and lipids, as well as urine albumin and creatinine, were measured and GFR was calculated.
Results: Patients who carried the rs4821481 polymorphism had significantly higher urinary excretion of albumin (P < 0.05) and insignificantly lower GFR values (P = 0.08).
The frequency of rs4821481 SNP was 22.8% in patients without DN versus 28% in the DN group, which was not statistically significant.
Only 2% and 3% of patients without DN and with DN, respectively, had two copies of the C allele.
No significant association was found between the rs4821481 polymorphism and DN (OR [95% CI] 1.56 [0.79 - 3.08], P = 0.19).
Conclusions: Although we found an association between MYH9 gene polymorphism and urinary albumin excretion, the results did not show a significant association between MYH9 polymorphism (rs4821481) and risk of DN in Iranian diabetic patients.
American Psychological Association (APA)
Asdadollahpour, Effat& Daneshpourm, Maryam& Khayat, Bahareh Sedaghati& Hashemiaghdam, Arsalan& Amoli, Mahsa Muhammad& Qorbani, Mustafa…[et al.]. 2017. Non-muscle myosin heavy chain 9 gene (MYH9) Polymorphism (rs4821481) is associated with urinary albumin excretion in Iranian diabetic patients. Iranian Red Crescent Medical Journal،Vol. 19, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-766553
Modern Language Association (MLA)
Asdadollahpour, Effat…[et al.]. Non-muscle myosin heavy chain 9 gene (MYH9) Polymorphism (rs4821481) is associated with urinary albumin excretion in Iranian diabetic patients. Iranian Red Crescent Medical Journal Vol. 19, no. 1 (Jan. 2017), pp.1-6.
https://search.emarefa.net/detail/BIM-766553
American Medical Association (AMA)
Asdadollahpour, Effat& Daneshpourm, Maryam& Khayat, Bahareh Sedaghati& Hashemiaghdam, Arsalan& Amoli, Mahsa Muhammad& Qorbani, Mustafa…[et al.]. Non-muscle myosin heavy chain 9 gene (MYH9) Polymorphism (rs4821481) is associated with urinary albumin excretion in Iranian diabetic patients. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-766553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-766553