The effect of IFN-B1a on biochemical factors in multiple sclerosis patients
Joint Authors
Nuruzi, Saam
Meimand, Husayn Ali Ibrahim
Arababbadi, Muhammad Kazimi
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 3 (31 Mar. 2017), pp.1-8, 8 p.
Publisher
Publication Date
2017-03-31
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Multiple sclerosis (MS) is known as a progressive and demyelinating disease, which involves biochemical changes.
Objectives : To evaluate the effect of IFN_-1a therapy on the biochemical factors in the MS patients.
Methods: In this descriptive study, 30MSpatients and 30 healthy controls were included.
The study was conducted in the Neurology Center at the Shefa hospital, Kerman, Iran from September 2013 to July 2015.
The patients’ blood test was taken before and after six monthsof IFN_-1a therapyandthe biochemical factors (LDH, AST, ALT, Creatinine, Uric acid, Malondialdehyde (MDA)andnitric oxide (NO) were measured in all the samples.
The participants were divided to three groups, namely main group (30 patients), females (22 patients) and males (8 patients).
Before taking the medicine, the groups were compared to the control group.
After six months of taking the medicine, each group was compared to its former state before taking the drug.
Results : In the patients group (30 patients), a significant difference was observed in their measured biochemical factors in comparison to the control group (P = 0.001), however, after six months of using IFN_-1a, only MDA was shown in the main (P = 0.003) and female group (P = 0.003), and the ALT that was shown in the female group had a significant reduction in comparison to that before receiving IFN_-1a.
Conclusions : This study showed that IFN_-1a decreased oxidant impacts in MS patients, but had no influence in improving mitochondrial dysfunction.
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American Psychological Association (APA)
Nuruzi, Saam& Arababbadi, Muhammad Kazimi& Meimand, Husayn Ali Ibrahim& Asadikaram, Gholamreza. 2017. The effect of IFN-B1a on biochemical factors in multiple sclerosis patients. Iranian Red Crescent Medical Journal،Vol. 19, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-766604
Modern Language Association (MLA)
Nuruzi, Saam…[et al.]. The effect of IFN-B1a on biochemical factors in multiple sclerosis patients. Iranian Red Crescent Medical Journal Vol. 19, no. 3 (Mar. 2017), pp.1-8.
https://search.emarefa.net/detail/BIM-766604
American Medical Association (AMA)
Nuruzi, Saam& Arababbadi, Muhammad Kazimi& Meimand, Husayn Ali Ibrahim& Asadikaram, Gholamreza. The effect of IFN-B1a on biochemical factors in multiple sclerosis patients. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-766604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-766604