Dietary regulation of miR-33b and miR-29a in relationship to metabolic biomarkers of glucose and lipids in obese diabetic women : a randomized clinical controlled study
Joint Authors
Muhammadi, Sumayyah
Arefhosseini, Sayyid Rafie
Ibrahimi Mameghani, Mehrangiz
Fallah, Parviz
Zununi, Sepideh
Sulaymani, Masud
Dehkordi, Mahdi Banitalebi
Ghanbarian, Husayn
Asghari Jafarabadi, Muhammad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 1 (31 Jan. 2017), pp.1-10, 10 p.
Publisher
Publication Date
2017-01-31
Country of Publication
United Arab Emirates
No. of Pages
10
Main Subjects
Abstract EN
Background: MicroRNAs have recently been introduced as epigenetic regulators of glucose and lipid metabolic pathways, which are impaired in obesity and diabetes.
Objectives: We evaluated the effects of calorie-restricted diet therapy on the circulating levels of miR-33b and miR-29a in relationship to glucose and lipid metabolic parameters in obese patients with type 2 diabetes mellitus (T2DM).
Methods: This randomized clinical controlled trial was performed on 30 eligible obese women with T2DM, randomly divided into two groups (control group, n = 15; diet therapy group, n = 15) for 10 weeks.
Ten healthy women with normal weight were enrolled at the baseline of the study as controls.
Demographic information, dietary intake, and anthropometric and biochemical indices were obtained before and after the study.
Circulating miR-33b and miR-29a were assessed for all subjects using quantitative RT-PCR, and the fold change of each circulating miRNA was compared between groups.
Results: The circulating levels of miR-29a and miR-33b in the diabetic women were higher (0.40-fold) and lower (1.43-fold), respectively, than normal levels.
Diet therapy significantly increased the circulating level of miR-33b (P = 0.023, 0.97-fold upregulation) to normal levels.
This increase was independently correlated with caloric restriction (95%CI: -0.004 to -0.0001, P = 0.022) and 2hPPBS (95%CI: -0.009 to -0.001, P = 0.035).
No remarkable change was observed in circulating levels of miR-29a.
Conclusions: Our findings introduced a novel therapeutic effect of diet therapyoncirculatingmiRNAsin obese patients with T2DM.
MiR-33b is an important therapeutic target in the treatment and prevention of T2DM and its complications.
American Psychological Association (APA)
Muhammadi, Sumayyah& Ibrahimi Mameghani, Mehrangiz& Arefhosseini, Sayyid Rafie& Fallah, Parviz& Asghari Jafarabadi, Muhammad& Zununi, Sepideh…[et al.]. 2017. Dietary regulation of miR-33b and miR-29a in relationship to metabolic biomarkers of glucose and lipids in obese diabetic women : a randomized clinical controlled study. Iranian Red Crescent Medical Journal،Vol. 19, no. 1, pp.1-10.
https://search.emarefa.net/detail/BIM-766855
Modern Language Association (MLA)
Muhammadi, Sumayyah…[et al.]. Dietary regulation of miR-33b and miR-29a in relationship to metabolic biomarkers of glucose and lipids in obese diabetic women : a randomized clinical controlled study. Iranian Red Crescent Medical Journal Vol. 19, no. 1 (Jan. 2017), pp.1-10.
https://search.emarefa.net/detail/BIM-766855
American Medical Association (AMA)
Muhammadi, Sumayyah& Ibrahimi Mameghani, Mehrangiz& Arefhosseini, Sayyid Rafie& Fallah, Parviz& Asghari Jafarabadi, Muhammad& Zununi, Sepideh…[et al.]. Dietary regulation of miR-33b and miR-29a in relationship to metabolic biomarkers of glucose and lipids in obese diabetic women : a randomized clinical controlled study. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 1, pp.1-10.
https://search.emarefa.net/detail/BIM-766855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-10
Record ID
BIM-766855