Alteration of Alzheimer amyloid precursor protein after treatment with carbamazepine in colon cancer
Joint Authors
Zanjani, Taraneh Moini
Akbarzadeh, Ladan
Sabetkasaei, Masoumeh
Khazaei, Yalda
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 1 (31 Jan. 2017), pp.1-5, 5 p.
Publisher
Publication Date
2017-01-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Abstract EN
Background: Amyloid precursor protein (APP), which is involved in cell proliferation, is observed to be over expressed in human cancer.
Thus, it is crucial to investigate its role in cancer and suggest treatment strategies to alter its effects on cell growth.
Objectives: The main purpose of this study was to determine APP concentrations in colon cancer SW480 cell line after treatment with histone deacetylase inhibitors (HDACIs), namely valproic acid (VPA) and carbamazepine (CBZ).
Methods: In the present experimental study, carried out during the period 2014 - 2016 in Iran, 1000000 cells were seeded and incubated in a six-well plate for each sample preparation.
The cells were then treated with drugs and APP was evaluated.
The concentration of this protein was detected using the enzyme-linked immunosorbent assay (ELISA) method.
Results:We found that treatment with CBZ (P< 0.001) and VPA (P< 0.001) reduced the APP levels significantly compared to controls.
The APP level reduction by CBZ was 41.6% more than that by VPA.
Conclusions: The results of this study suggest that APP reduction by HDACIs can apparently play an important role in the treatment of colon cancer
American Psychological Association (APA)
Akbarzadeh, Ladan& Zanjani, Taraneh Moini& Sabetkasaei, Masoumeh& Khazaei, Yalda. 2017. Alteration of Alzheimer amyloid precursor protein after treatment with carbamazepine in colon cancer. Iranian Red Crescent Medical Journal،Vol. 19, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-766858
Modern Language Association (MLA)
Akbarzadeh, Ladan…[et al.]. Alteration of Alzheimer amyloid precursor protein after treatment with carbamazepine in colon cancer. Iranian Red Crescent Medical Journal Vol. 19, no. 1 (Jan. 2017), pp.1-5.
https://search.emarefa.net/detail/BIM-766858
American Medical Association (AMA)
Akbarzadeh, Ladan& Zanjani, Taraneh Moini& Sabetkasaei, Masoumeh& Khazaei, Yalda. Alteration of Alzheimer amyloid precursor protein after treatment with carbamazepine in colon cancer. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-766858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-766858