Highly efficient three-component synthesis of 5-substituted-1H-tetrazoles from aldehydes, hydroxylamine, and tetrabutylammonium azide using doped nano-sized copper (I)‎ oxide (Cu2O)‎ on melamine-formaldehyde resin

Abstract EN

A simple and facile one-pot three-component synthesis of 5-substituted 1H-tetrazole derivatives from aldehydes catalyzed by doped nano-sized Cu2O on melamine–formaldehyde resin (nano-Cu2O–MFR) is described.

In this protocol, treatment of structurally diverse aldehydes, hydroxylamine hydrochloride and tetrabutylammonium azide (TBAA) as an azide source in the presence of nano-Cu2O–MFR as an efficient heterogeneous nano-catalyst affords the corresponding 5-substituted 1H-tetrazoles in good to excellent yields.

The influence of different parameters on the progress of reaction was studied.

The nano-Cu2O–MFR is a cheap and stable nano catalyst that could be easily prepared, recycled and reused for many consecutive reaction runs without significant decrease in its activity.