An overlap of granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis

Abstract EN

We present a case report of overlap of granulomatosis with polyangiitis (GPA; formerly known as Wegener’s granulomatosis) and eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome).

We report a 45-year-old female who presented with rapidly progressive renal failure associated with fever, polyarthralgia, and respiratory symptoms with cytoplasmic antineutrophilic cytoplasmic antibody (ANCA) and proteinase (PR-3) antigen positivity.

Computerized tomography scan of the chest showed diffuse alveolar hemorrhage with renal biopsy revealing pauci-immune necrotizing crescentic glomerulonephritis with intense eosinophilic infiltration suggestive of eosinophilic GPA (EGPA).

Our patient had ANCA-associated vasculitis (AAV) with features suggestive of both GPA and EGPA.

She was treated with methylprednisolone and cyclophosphamide and attained remission after 2 weeks of therapy.

This is a rare report of a patient with AAV having features of both EGPA and GPA.