Synthesis of new beta-lactam, 2-thioxoimidazolidin-4-one and imidazole-5-one derivatives from thiosemicarbazide and their biological activity study
Author
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 30, Issue 2 (31 Aug. 2017), pp.84-99, 16 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2017-08-31
Country of Publication
Iraq
No. of Pages
16
Main Subjects
Topics
Abstract EN
New derivatives of thiosemicarbazide were synthesized by reaction of different aromatic aldehydes and ketones with thiosemicarbazide to give schiff-bases 1(a-d) .
schiff-bases have been used for synthesized the thioimidazolidine 2(a-d) by reaction of schiff-bases with ethyl chloroacetatein in presence of anhydrous sodium acetate that transformed part of it in to Beta-lactam 3(a-b) compounds with phenyl acetic acid and thionyl chloride , The compounds 4(a-b) came from the reactor of 4-bromobenzaldehyde with compounds 2(a-b) , as well as reaction of compounds 2(b-d) with methyl iodide and anhydrous potassium carbonate to give 5 (b-d) , then added hydrazine hydrate formed 6(b-d) , then reaction with acetic anhydride to prepare 7(b-d) , The biological activity of the synthesized compounds was also studied .
All newly compounds were characterized by using the proton nuclear magnetic resonance (1H-NMR) ,mass spectra (Ms) , fourier transform infrared spectroscopy (FTIR) ,ultraviolet (UV) spectroscopy spectra , and studied their physical properties.
American Psychological Association (APA)
Hamid, Rua Majid Abd al-Amir. 2017. Synthesis of new beta-lactam, 2-thioxoimidazolidin-4-one and imidazole-5-one derivatives from thiosemicarbazide and their biological activity study. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 30, no. 2, pp.84-99.
https://search.emarefa.net/detail/BIM-768249
Modern Language Association (MLA)
Hamid, Rua Majid Abd al-Amir. Synthesis of new beta-lactam, 2-thioxoimidazolidin-4-one and imidazole-5-one derivatives from thiosemicarbazide and their biological activity study. Ibn al-Haitham Journal for Pure and Applied Science Vol. 30, no. 2 (2017), pp.84-99.
https://search.emarefa.net/detail/BIM-768249
American Medical Association (AMA)
Hamid, Rua Majid Abd al-Amir. Synthesis of new beta-lactam, 2-thioxoimidazolidin-4-one and imidazole-5-one derivatives from thiosemicarbazide and their biological activity study. Ibn al-Haitham Journal for Pure and Applied Science. 2017. Vol. 30, no. 2, pp.84-99.
https://search.emarefa.net/detail/BIM-768249
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 94-99
Record ID
BIM-768249