Modified simplex-spectrophotometric determination of clonazepam via charge-transfer complexation
Joint Authors
Zankanah, Fayizah Hazim
Dikran, Sarmad Bahjat
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 30, Issue 2 (31 Aug. 2017), pp.112-124, 13 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2017-08-31
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Topics
Abstract EN
A simple, sensitive, accurate, and precise spectrophotometric method for the determination of clonazepam (CLNZ) was developed.
The method is based on charge transfer reaction between CLNZ and p-Bromanil (p-Br) to form a colored complex.
The optimum conditions of complex formation were investigated by (1).
Unvariable method, for the optimization of reagent concentration, base concentration, temperature, and time.
(2).
Multivariable simplex method including the effect of three experimental factors via; reagent concentration, concentration of NaOH and time.
The linearity range of CLNZ was (1-30) μg.mL-1 at 378 nm under condition established via simplex method with molar absorptivity (1.9069x104) L.mol-1.cm-1, Sandell's sensitivity index (0.0165) μg.cm-2, detection limit of 0.2957μg.mL-1, quantification limit 0.9858μg.mL-1 and association constant of the formed complex (2333.3).
The proposed method has been successfully applied for the determination of CLNZ in pure form and pharmaceutical preparations.
American Psychological Association (APA)
Zankanah, Fayizah Hazim& Dikran, Sarmad Bahjat. 2017. Modified simplex-spectrophotometric determination of clonazepam via charge-transfer complexation. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 30, no. 2, pp.112-124.
https://search.emarefa.net/detail/BIM-768262
Modern Language Association (MLA)
Zankanah, Fayizah Hazim& Dikran, Sarmad Bahjat. Modified simplex-spectrophotometric determination of clonazepam via charge-transfer complexation. Ibn al-Haitham Journal for Pure and Applied Science Vol. 30, no. 2 (2017), pp.112-124.
https://search.emarefa.net/detail/BIM-768262
American Medical Association (AMA)
Zankanah, Fayizah Hazim& Dikran, Sarmad Bahjat. Modified simplex-spectrophotometric determination of clonazepam via charge-transfer complexation. Ibn al-Haitham Journal for Pure and Applied Science. 2017. Vol. 30, no. 2, pp.112-124.
https://search.emarefa.net/detail/BIM-768262
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 118-124
Record ID
BIM-768262