Formulation characterization and evaluation of meloxicam nanoemulgel to be used topically
Other Title(s)
تحضير و صياغة و تقييم هلام المستحلب النانوي للميلوكسيام للاستخدام الموضعي
Joint Authors
Drais, Haydar Kazim
Husayn, Ahmad Abbas
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 26, Issue 1 (30 Jun. 2017), pp.9-16, 8 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract EN
Meloxicam is a non-steroidal anti-inflammatory drug.
It is practically insoluble in water.
It is associated with gastrointestinal side effects at high doses on long term treatment.
The aim of this investigation to formulate and evaluate gellified nanoemulsion of meloxicam as a topical dosage form to enhance meloxicam therapeutic activity and reduce systemic side effect.
The pseudo ternary phase diagrams were made, including the oil mixture which is composed of almond oil and peppermint oil at a ratio (1:2), variable surfactant mixture (S mix) which are tween 80 and ethanol at ratios of (1:1, 2:1, 3:1, and 4:1) and double distilled water.
Slow dripping of double distilled water to the combination of the oil mixture and Smix was performed to get nanoemulsion.
The pseudo ternary phase diagram that has a greater nanoemulsifying area was contained Smix ratio (3 : 1) from which seven formulas of nanoemulsion (NE1-NE7) were taken for characterization of prepared nanoemulsions and to prepare nanoemulgel formulas (NF1-NF7).
The seven nanoemulgel formulas were subjected to various evaluations.
NF1 was the selected formula and investigated for its stability and morphology.
Atomic force microscopy (AFM) indicated that the optimized formula (NF1) was nanosized particle nearly spherical in shape and smooth surface globules, this indicates stability of optimized nanoemulgel (NF1).
It can be concluded that the selected formula (NF1) is an effective alternative for the topical delivery of meloxicam.
American Psychological Association (APA)
Drais, Haydar Kazim& Husayn, Ahmad Abbas. 2017. Formulation characterization and evaluation of meloxicam nanoemulgel to be used topically. Iraqi Journal of Pharmaceutical Sciences،Vol. 26, no. 1, pp.9-16.
https://search.emarefa.net/detail/BIM-768876
Modern Language Association (MLA)
Drais, Haydar Kazim& Husayn, Ahmad Abbas. Formulation characterization and evaluation of meloxicam nanoemulgel to be used topically. Iraqi Journal of Pharmaceutical Sciences Vol. 26, no. 1 (2017), pp.9-16.
https://search.emarefa.net/detail/BIM-768876
American Medical Association (AMA)
Drais, Haydar Kazim& Husayn, Ahmad Abbas. Formulation characterization and evaluation of meloxicam nanoemulgel to be used topically. Iraqi Journal of Pharmaceutical Sciences. 2017. Vol. 26, no. 1, pp.9-16.
https://search.emarefa.net/detail/BIM-768876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 16
Record ID
BIM-768876