Formulation and evaluation of sustained and raft forming antacid tablet
Other Title(s)
تصييغ و تقييم أقراص مضادات حموضة مديدة و طافية
Author
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 26, Issue 1 (30 Jun. 2017), pp.26-32, 7 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
Antacids have been widely used in the treatment of various gastric and duodenal disorders such as heartburn, reflux esophagitis, gastritis, irritable stomach, gastric and duodenal ulcers.
A pHresponsive of bi-polymer of sodium alginate and pectin have been studied as raft-forming polymers using sodium bicarbonate and calcium carbonate as gas-generating and calcium ion sources.
The aim of study was to formulate and evaluate mono and bilayer tablets of floating and sustained release antacid delivery systems using sodium carboxy methyl cellulose as a gel forming substance, calcium and magnesium carbonate as sources of acid neutralizing and carbon dioxide gas generators agents upon contact with acidic solution.
The effect of the formulation contents on the buoyancy has been investigated.
In addition to, the antacid activities of intact and pulverized tablets have been studied.
The result obtained showed that the buoyance is remarkably affected by the percentages of sodium carboxy methyl cellulose and carbonates salts.
All formulas of mono and bilayer tablets revealed sustained action of acid neutralization and raft formation.
Besides, bilayer tablets showed a significant and higher level of acid neutralizing capacity than monolayer tablets.
Moreover, the pulverized of bilayer tablets exhibited significant and higher acid neutralizing capacity at raft than that at bulk of artificial gastric juice medium.
American Psychological Association (APA)
al-Lami, Muhammad Sabbar. 2017. Formulation and evaluation of sustained and raft forming antacid tablet. Iraqi Journal of Pharmaceutical Sciences،Vol. 26, no. 1, pp.26-32.
https://search.emarefa.net/detail/BIM-768888
Modern Language Association (MLA)
al-Lami, Muhammad Sabbar. Formulation and evaluation of sustained and raft forming antacid tablet. Iraqi Journal of Pharmaceutical Sciences Vol. 26, no. 1 (2017), pp.26-32.
https://search.emarefa.net/detail/BIM-768888
American Medical Association (AMA)
al-Lami, Muhammad Sabbar. Formulation and evaluation of sustained and raft forming antacid tablet. Iraqi Journal of Pharmaceutical Sciences. 2017. Vol. 26, no. 1, pp.26-32.
https://search.emarefa.net/detail/BIM-768888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 31-32
Record ID
BIM-768888