The effects of ERCC 1 expression levels on the chemo resistance of breast cancer patients treated with platinum-based adjuvant chemotherapy
Joint Authors
al-Tai, Muhammad Ibrahim Nadir Mahmud
Karim, Suhad K.
Abd al-Majid, Ban A.
Source
Iraqi Journal of Biotechnology
Issue
Vol. 16, Issue 1 (31 Mar. 2017), pp.106-110, 5 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2017-03-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Excision repair cross-complementing 1 (ercc1) is reported to be involved in the sensitivity of cancer patients to platinum-based chemotherapy.
The present study to evaluate the effects of ERCC1 expression on the chemosensitivity of platinum agents in breast cancer.
ercc1 expression levels were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).
The results demonstrated patients with low ercc1 levels had chemosensitive than those with high ercc1 levels.
These results suggest that overexpression of ercc1 is correlated with platinum drug resistance in breast cancer patients .The patients with low levels of ercc1 expression demonstrate a benefit from platinum-based adjuvant chemotherapy.
American Psychological Association (APA)
Karim, Suhad K.& Abd al-Majid, Ban A.& al-Tai, Muhammad Ibrahim Nadir Mahmud. 2017. The effects of ERCC 1 expression levels on the chemo resistance of breast cancer patients treated with platinum-based adjuvant chemotherapy. Iraqi Journal of Biotechnology،Vol. 16, no. 1, pp.106-110.
https://search.emarefa.net/detail/BIM-769173
Modern Language Association (MLA)
Karim, Suhad K.…[et al.]. The effects of ERCC 1 expression levels on the chemo resistance of breast cancer patients treated with platinum-based adjuvant chemotherapy. Iraqi Journal of Biotechnology Vol. 16, no. 1 (2017), pp.106-110.
https://search.emarefa.net/detail/BIM-769173
American Medical Association (AMA)
Karim, Suhad K.& Abd al-Majid, Ban A.& al-Tai, Muhammad Ibrahim Nadir Mahmud. The effects of ERCC 1 expression levels on the chemo resistance of breast cancer patients treated with platinum-based adjuvant chemotherapy. Iraqi Journal of Biotechnology. 2017. Vol. 16, no. 1, pp.106-110.
https://search.emarefa.net/detail/BIM-769173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 109-110
Record ID
BIM-769173