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Association of genetic polymorphisms in a sample of Iraqi patients with type2 diabetes mellitus
Joint Authors
Abd al-Rida, Rua H.
Qandala, Nuha Juzif
Source
Iraqi Journal of Biotechnology
Issue
Vol. 15, Issue 3 (31 Dec. 2016), pp.78-84, 7 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
Type 2 Diabetes (T2D) is a progressive condition that is characterized by high blood sugar (hyperglycemia)‚ with T2D the body either resist the effect of insulin or does not produce enough insulin.
In order to underline the role of the genes involved in this study‚ we investigate ‚using PCR-RFLP for CTLA-4 gene ‚ PCR-RFLP and sequencing for VDR gene.
Polymorphisms of two single nucleotide polymorphisms (SNPs) belonging to both genes in 60 T2D patients and 30 healthy control from Iraqi population.
The present local study demonstrated that VDR FoK-I‚ FF genotype (P = 0.04) and F‚f alleles (P=0.07) frequencies were significantly associated while VDR Bsm-I was significantly non-associated.
CTLA-4 -1722(T>C) and +49 (A>G) shows non-significant association.
These result suggest the involvement of VDR gene in the genetic susceptibility to T2D.
Interestingly FoK-I‚ contributes to increasing the risk to the disease in our population.
However‚ Further studies are require to confirmed this finding.
American Psychological Association (APA)
Abd al-Rida, Rua H.& Qandala, Nuha Juzif. 2016. Association of genetic polymorphisms in a sample of Iraqi patients with type2 diabetes mellitus. Iraqi Journal of Biotechnology،Vol. 15, no. 3, pp.78-84.
https://search.emarefa.net/detail/BIM-769539
Modern Language Association (MLA)
Abd al-Rida, Rua H.& Qandala, Nuha Juzif. Association of genetic polymorphisms in a sample of Iraqi patients with type2 diabetes mellitus. Iraqi Journal of Biotechnology Vol. 15, no. 3 (2016), pp.78-84.
https://search.emarefa.net/detail/BIM-769539
American Medical Association (AMA)
Abd al-Rida, Rua H.& Qandala, Nuha Juzif. Association of genetic polymorphisms in a sample of Iraqi patients with type2 diabetes mellitus. Iraqi Journal of Biotechnology. 2016. Vol. 15, no. 3, pp.78-84.
https://search.emarefa.net/detail/BIM-769539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 83-84
Record ID
BIM-769539