Histological changes of liver, kidney and brain in uninephrectomized male rats exposed to fluoxetine

Abstract EN

Kidney is the organ of humans and animals body which responsible for purification of blood from waste substances, the process of removing kidney or part of the kidney called nephrectomy.

The depression disease mostly occurs in unhealthy person; it is commonly treated with fluoxetine.

The purpose of this investigation to determine the histological effects of fluoxetine on liver, kidney, cerebrum and cerebellum of uninephrectomized male rats; rats were divided randomly into two groups, uninephrectomized control group and uninephrectomized fluoxetine treated group.

After one month administration of fluoxetine, histological alteration observed in liver such as a little hydropic degeneration of the hepatocytes and inflammatory leucocyte infiltration.

Hemorrhagic area and shrinking of glomerulus appeared in the cortex region of kidney, degeneration of kidney tubule epithelial cells and dilation in some kidney tubules were detected in medulla region as a result of exposing uninephrectomized rats to fluoxetine.

Histological slides of cerebrum and cerebellum uninephrectomized rats which exposed to fluoxetine showed dead pyramidal and purkinje cells respectively.

In conclusion, light microscopic examinations showed that fluoxetine had a little effect on the liver, kidney, cerebrum and cerebellum