Histological changes of liver, kidney and brain in uninephrectomized male rats exposed to fluoxetine
Joint Authors
Hamad, Sarkawt H.
Hasan, Dlshad Husayn
Mahmud, Nizar Muhammad Sharif
Rasul, Khidr Husayn
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 28, Issue 6 (31 Dec. 2016), pp.106-121, 16 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
16
Main Subjects
Topics
Abstract EN
Kidney is the organ of humans and animals body which responsible for purification of blood from waste substances, the process of removing kidney or part of the kidney called nephrectomy.
The depression disease mostly occurs in unhealthy person; it is commonly treated with fluoxetine.
The purpose of this investigation to determine the histological effects of fluoxetine on liver, kidney, cerebrum and cerebellum of uninephrectomized male rats; rats were divided randomly into two groups, uninephrectomized control group and uninephrectomized fluoxetine treated group.
After one month administration of fluoxetine, histological alteration observed in liver such as a little hydropic degeneration of the hepatocytes and inflammatory leucocyte infiltration.
Hemorrhagic area and shrinking of glomerulus appeared in the cortex region of kidney, degeneration of kidney tubule epithelial cells and dilation in some kidney tubules were detected in medulla region as a result of exposing uninephrectomized rats to fluoxetine.
Histological slides of cerebrum and cerebellum uninephrectomized rats which exposed to fluoxetine showed dead pyramidal and purkinje cells respectively.
In conclusion, light microscopic examinations showed that fluoxetine had a little effect on the liver, kidney, cerebrum and cerebellum
American Psychological Association (APA)
Rasul, Khidr Husayn& Mahmud, Nizar Muhammad Sharif& Hamad, Sarkawt H.& Hasan, Dlshad Husayn. 2016. Histological changes of liver, kidney and brain in uninephrectomized male rats exposed to fluoxetine. ZANCO Journal of Pure and Applied Sciences،Vol. 28, no. 6, pp.106-121.
https://search.emarefa.net/detail/BIM-769945
Modern Language Association (MLA)
Rasul, Khidr Husayn…[et al.]. Histological changes of liver, kidney and brain in uninephrectomized male rats exposed to fluoxetine. ZANCO Journal of Pure and Applied Sciences Vol. 28, no. 6 (2016), pp.106-121.
https://search.emarefa.net/detail/BIM-769945
American Medical Association (AMA)
Rasul, Khidr Husayn& Mahmud, Nizar Muhammad Sharif& Hamad, Sarkawt H.& Hasan, Dlshad Husayn. Histological changes of liver, kidney and brain in uninephrectomized male rats exposed to fluoxetine. ZANCO Journal of Pure and Applied Sciences. 2016. Vol. 28, no. 6, pp.106-121.
https://search.emarefa.net/detail/BIM-769945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 120-121
Record ID
BIM-769945