Factor II prothrombin (G20210A) mutation among healthy individuals in Erbil Iraq
Other Title(s)
عامل الثاني البروثرومبين (G20210A) طفرات الجينية بين الأفراد الأصحاء في أربيل العراق
Joint Authors
Jubrael, Jaladet M. S.
Nerweyi, Faridah F. A.
Husayn, Salar S.
Source
Issue
Vol. 7, Issue 2 (31 Dec. 2013), pp.9-15, 7 p.
Publisher
University of Duhok College of Medicine
Publication Date
2013-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
\Background and Objectives The factor II (Prothrombin) is the precursor of thrombin.
Factor II G20210A mutation is one of the genetic risk factors for thrombosis and it is associated with elevated prothrombin levels.
The goal of this study was to study the frequency of the Factor II mutation in healthy individuals in Erbil-Iraq.
Methods A total of 100 healthy individuals attending the premarital screening center in Erbil city were recruited.
Factor II gene polymorphism was investigated in all of them by the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).
Results Factor ll prothrombin (G20210A) mutation was documented heterozygous state in 2 subjects (2%).
Conclusions The prevalence of Prothrombin G20210A mutation differs in different countries and ethnic groups, being highest in Caucasians, especially those in the Southern Europe and in the Eastern Mediterranean; its frequency in Erbil appears slightly lower than these reports and than that from Duhok, probably implying limited role in pathogenesis of venous thrombosis in the former province
American Psychological Association (APA)
Nerweyi, Faridah F. A.& Husayn, Salar S.& Jubrael, Jaladet M. S.. 2013. Factor II prothrombin (G20210A) mutation among healthy individuals in Erbil Iraq. Duhok Medical Journal،Vol. 7, no. 2, pp.9-15.
https://search.emarefa.net/detail/BIM-771007
Modern Language Association (MLA)
Nerweyi, Faridah F. A.…[et al.]. Factor II prothrombin (G20210A) mutation among healthy individuals in Erbil Iraq. Duhok Medical Journal Vol. 7, no. 2 (Dec. 2013), pp.9-15.
https://search.emarefa.net/detail/BIM-771007
American Medical Association (AMA)
Nerweyi, Faridah F. A.& Husayn, Salar S.& Jubrael, Jaladet M. S.. Factor II prothrombin (G20210A) mutation among healthy individuals in Erbil Iraq. Duhok Medical Journal. 2013. Vol. 7, no. 2, pp.9-15.
https://search.emarefa.net/detail/BIM-771007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 12-13
Record ID
BIM-771007