Study the effect of proanthocyanidin and ranitidine on haematology and biochemical parameters in adult female rabbits with gastric ulceration induced by indomethacin
Other Title(s)
دراسة تأثير بروانثوسياندين و الرانتدين على المعايير الدموية و الكيموحيوية في إناث الأرانب البالغة المستحدثة القرحة بواسطه الأندوميثاسين
Joint Authors
Abd al-Razzaq, Abrar Salman
al-Masudi, Iman Abbud
al-Said, Muna Hamid Mahmud
Source
Basrah Journal of Veterinary Research
Issue
Vol. 15, Issue 1 (30 Jun. 2016), pp.132-160, 29 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2016-06-30
Country of Publication
Iraq
No. of Pages
29
Main Subjects
Abstract EN
The study was conducted in Collage of Veterinary Medicine Basrah University,to evaluate the effect of proanthocyanidin and ranitidin on gastric ulcer, haematological and biochemical parameters changes by using female rabbits with acute gastric lesions induced by indomethacin.The study done on (30)adult female rabbits, their weight ranged between (1500-2000.0mg); divided into five groups, each group consist of six rabbits as the following: Group1:- healthy (negative control group) administrated normal saline (0.9 of normal saline) for 10 days; Group 2:-given indomethacin 75mgkg B.W.
for two days(positive control group); Group 3:- at first given indomethacin 75mgkg B.W.
for two days, then treated with proanthocyanidin(PA) 100mgkg B.W.
for 10 days; Group 4, initially given indomethacin 75mgkg for two days, then treated with proanthocyanidin(PA) 200mgkg for 10 days; Group 5, given indomethacin 75mgkg for two days, then treated with ranitidin 50mgkg for10 days.The results showed that proanthocyanidin(PA) and ranitidin caused significant reduction (P≤0.05) in gastric volume, ulcer area, serum MDA, gastric tissue MDA while significant increase (P≤0.05) in mucin and gastric pH.
It also revealed significant decrease (P≤0.05) in glucose concentration in rabbits treated with proanthocyanidin compared to positive control group while showedno-significant change in glucose concentration in rabbits treated with ranitidine compared with positive control group.
It also, showed significant increase (P≤0.05) in Red Blood Cell(RBC),Hemoglobin(Hb) andMean Corpuscle hemoglobin concentration(MCHC) in rabbit treated with proanthocyanidin or ranitidin, while there was significant decrease (P≤0.05) in Mean Corpuscle Volume(MCV) in rabbits treated with proanthocyanidin in dose of 100mgkgand ranitidine in a dose of 50mg/kg with non-significant change of MCV in female rabbits with gastric ulceration treated with proanthocyanidin at dose 200 compared with positive control group.It showed non-significant changes in White Blood Cell (WBC) of female rabbits with gastric ulceration treated with proanthocyanidin compared with positive and negative control groups, while the results showed significant decrease (P≤0.05) in WBC of female rabbits with gastric ulceration treated with ranitidine group compared with positive and negative control groups and the other groups.
The study revealed significant decrease (P≤0.05) in total cholesterol, triglyceride, Low Density Lipoprotein(LDL) and very Low Density Lipoprotein(VLDL) of female rabbits with gastric ulceration treated with proanthocyanidin and ranitidine group compared with positive control group while it showed significant increase (P≤0.05) in High Density Lipoprotein (HDL) in rabbits treated with proanthocyanidin and ranitidine group compared with positive control group.
It is concluded that proanthocyanidin extract of the grape seeds(Vitis vinifera)displayed good antiulcer activity, hypoglycemia effect, amelioration of heamatological parameters and improve dyslipidemia corroborating the folk use of Vitis vinifera preparations, and contributing for its pharmacological validation.
American Psychological Association (APA)
Abd al-Razzaq, Abrar Salman& al-Said, Muna Hamid Mahmud& al-Masudi, Iman Abbud. 2016. Study the effect of proanthocyanidin and ranitidine on haematology and biochemical parameters in adult female rabbits with gastric ulceration induced by indomethacin. Basrah Journal of Veterinary Research،Vol. 15, no. 1, pp.132-160.
https://search.emarefa.net/detail/BIM-771163
Modern Language Association (MLA)
Abd al-Razzaq, Abrar Salman…[et al.]. Study the effect of proanthocyanidin and ranitidine on haematology and biochemical parameters in adult female rabbits with gastric ulceration induced by indomethacin. Basrah Journal of Veterinary Research Vol. 15, no. 1 (Jun. 2016), pp.132-160.
https://search.emarefa.net/detail/BIM-771163
American Medical Association (AMA)
Abd al-Razzaq, Abrar Salman& al-Said, Muna Hamid Mahmud& al-Masudi, Iman Abbud. Study the effect of proanthocyanidin and ranitidine on haematology and biochemical parameters in adult female rabbits with gastric ulceration induced by indomethacin. Basrah Journal of Veterinary Research. 2016. Vol. 15, no. 1, pp.132-160.
https://search.emarefa.net/detail/BIM-771163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 153-160
Record ID
BIM-771163