The protective impact of vitamin E against atenolol effect on Ca+2, Testosteron and FSH in male rats
Joint Authors
Source
Kufa Journal for Veterinary Medical Sciences
Issue
Vol. 7, Issue 2 (31 Dec. 2016), pp.151-157, 7 p.
Publisher
University of Kufa Faculty of Veterinary Medicine
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Background and objective: Atenolol is β1-selective antagonist nonetheless this selectivity is not absolute and at higher dosages atenolol represses β-2 Adrenoceptors mainly located in bronchial and vascular musculature, alsoβ-blocker atenolol effects on testosterone and FSH production.
Therefore ,this study was designed to investigate the possible protective effect of vitamin E on reproductive efficiency in male rats exposed to atenolol.
Materials and methods:Thirty-two healthy adult males Wistar rats at random divided into four equal groups and treatment for 56 days as follows:-First group (control):Animals in this group received tap water and served as control.Second group (group T1):Animal in this group will be receive atenolol orally at dose (100mg/kg/day).Third group (group T2):Animal in this group will be receive Vit.E (800IU /B.W.) orally and Fourth group (group T3):Animal in this group will be receive Vit.E (800IU/B.W.) and atenolol at dose (100mg/kg/B.W.) orally.
Results: serum level of serum testosterone in control group was 1.51±0.21 ng/ml, and it significantly decreased in atenolol treated group (0.74±0.008 ng/ml),.Serum level of FSH in the control group was (4.87±0.03 mIU /ml) while it significantly reduced in atenolol treated group (2.69±0.15mIU/ml), also the results showed that atenolol was a significantly decrease the Ca+2 concentration to (1.20 ± 0.15 mg/dl) in contrast to control group.
Conclusion: Vitamin E improve significantly the levels of serum FSH and testosterone in in atenolol treated rats.
American Psychological Association (APA)
Abbas, Safa M.& Khalil, Luma W.. 2016. The protective impact of vitamin E against atenolol effect on Ca+2, Testosteron and FSH in male rats. Kufa Journal for Veterinary Medical Sciences،Vol. 7, no. 2, pp.151-157.
https://search.emarefa.net/detail/BIM-771398
Modern Language Association (MLA)
Abbas, Safa M.& Khalil, Luma W.. The protective impact of vitamin E against atenolol effect on Ca+2, Testosteron and FSH in male rats. Kufa Journal for Veterinary Medical Sciences Vol. 7, no. 2 (Dec. 2016), pp.151-157.
https://search.emarefa.net/detail/BIM-771398
American Medical Association (AMA)
Abbas, Safa M.& Khalil, Luma W.. The protective impact of vitamin E against atenolol effect on Ca+2, Testosteron and FSH in male rats. Kufa Journal for Veterinary Medical Sciences. 2016. Vol. 7, no. 2, pp.151-157.
https://search.emarefa.net/detail/BIM-771398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 155-157
Record ID
BIM-771398