Hyperuricemia among patients with metabolic syndrome attending Duhok diabetes center

Abstract EN

Background and objectives Hyperuricemia is known to be associated with type2 Diabetes Mellitus (type 2 DM) and metabolic syndrome.

However, this association still needs to be delineated in our population .The aims of this study were to evaluate the prevalence of hyperuricemia in Kurdish type 2 DM population and to explore the metabolic factors clustering with hyperuricemia for patients with metabolic syndrome.

Methods Across-sectional study was conducted on 400 patients with metabolic syndrome .They were selected from patients diagnosed as type 2 DM or being treated with antidiabetic drugs who visited Duhok Diabetes Center during the period of the study(n = 3678).The patients were divided into quartile according to their uric acid levels, lowest(first) quartile to the highest(fourth) quartile.

The metabolic syndrome was defined according to the ATP-111 criteria; we exclude patients treated for hyperuricemia.

Results The prevalence of hyperuricemia was 8.0% .The age prevalence of hyperuricemia was 5.8 % in the patients aged 40-60 years and 2.2 % in those aged more than 60 years .The mean serum uric acid was 4.98 mg/dl(95%Cl 4.79-5.15) for males and 4.18 mg/dl (95 %Cl 4.01-4.35) for females.

In ANOVA analysis, patients with first quartile (uric acid< 4.0 mg/dl) were associated with lower mean values of waist circumference, blood pressure, triglycerides, blood glucose, insulin and HOMA-IR; but higher values of HDL-cholesterol than those with this comorbidity.

A significant correlation between serum uric acid and insulin resistance was observed(r=0.344, p=0.01), and a less significant value with waist circumference(r=0.125, p<0.05) and triglycerides (r=0.206, p<0.05).

Conclusions In patients with metabolic syndrome, about half have uric acid levels (>4.0 to <7.0 mg/dl) and one out of 10 has hyperuricemia.

The most determinant of hyperuricemia is waist circumference and insulin resistance.