P53 protein expression in dental follicle, dentigerous cyst, odontogenic keratocyst, and inflammatory subtypes of cysts : an immunohistochemical study
Joint Authors
Fatimah, Mashhadi Abbas
Sepideh, Arab
Seyedeh, Sara Bagheri
Nazanin, Mahdawi
Source
Issue
Vol. 32, Issue 3 (31 May. 2017), pp.227-232, 6 p.
Publisher
Publication Date
2017-05-31
Country of Publication
Oman
No. of Pages
6
Main Subjects
Abstract EN
Objectives: An odontogenic keratocyst (OKC) is a developmental odontogenic cyst with aggressive clinical behavior.
This cyst shows a different growth mechanism from the more common dentigerous cyst and now has been renamed as a keratocystic odontogenic tumor (KCOT).
Inflammation can assist tumor growth via different mechanisms including dysregulation of the p53 gene.
This study aims to assess and compare the expression of tumor suppressor gene p53 in inflamed and non-inflamed types of OKC and dentigerous cyst.
Methods: Immunohistochemical expression of p53 was assessed in 14 cases of dental follicle, 34 cases of OKC (including 18 inflamed OKCs), and 31 cases of dentigerous cyst (including 16 inflamed cysts).
Results: The mean percentage of p53 positive cells was 0.7% in dental follicles, 5.4% in non-inflamed OKCs, 17.3% in inflamed OKCs, 1.2% in non-inflamed dentigerous cysts, and 2.2% in inflamed dentigerous cysts.
The differences between the groups were statistically significant (p < 0.050) except for the difference between inflamed and non-inflamed dentigerous cysts, and between dental follicle and non-inflamed dentigerous cyst.
Conclusions: The difference in p53 expression in OKC and dentigerous cyst can explain their different growth mechanism and clinical behavior.
Inflammation is responsible for the change in behavior of neoplastic epithelium of OKC via p53 overexpression
American Psychological Association (APA)
Fatimah, Mashhadi Abbas& Sepideh, Arab& Seyedeh, Sara Bagheri& Nazanin, Mahdawi. 2017. P53 protein expression in dental follicle, dentigerous cyst, odontogenic keratocyst, and inflammatory subtypes of cysts : an immunohistochemical study. Oman Medical Journal،Vol. 32, no. 3, pp.227-232.
https://search.emarefa.net/detail/BIM-772329
Modern Language Association (MLA)
Fatimah, Mashhadi Abbas…[et al.]. P53 protein expression in dental follicle, dentigerous cyst, odontogenic keratocyst, and inflammatory subtypes of cysts : an immunohistochemical study. Oman Medical Journal Vol. 32, no. 3 (May. 2017), pp.227-232.
https://search.emarefa.net/detail/BIM-772329
American Medical Association (AMA)
Fatimah, Mashhadi Abbas& Sepideh, Arab& Seyedeh, Sara Bagheri& Nazanin, Mahdawi. P53 protein expression in dental follicle, dentigerous cyst, odontogenic keratocyst, and inflammatory subtypes of cysts : an immunohistochemical study. Oman Medical Journal. 2017. Vol. 32, no. 3, pp.227-232.
https://search.emarefa.net/detail/BIM-772329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 231-232
Record ID
BIM-772329