Prevalence and risk factors for sulfadoxine antibody among patients undergoing treatment for malaria in Benin City, Nigeria

Joint Authors

Ikuoyogie, Kingsley
Ogefere, Helen Oroboghae
Omoregie, Richard

Source

Oman Medical Journal

Issue

Vol. 32, Issue 3 (31 May. 2017), pp.207-213, 7 p.

Publisher

Oman Medical Specialty Board

Publication Date

2017-05-31

Country of Publication

Oman

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Objectives: Because of lack of data on the prevalence of sulfadoxine antibody, this study was conducted to determine the prevalence of sulfadoxine antibodies and its possible risk factors.

Methods: Blood specimens were collected from 500 patients undergoing treatment for malaria at Central Hospital, Benin City, Nigeria.

A structured questionnaire was used to collect information and sociodemographic data.

Sulfadoxine antibodies were detected by drug absorption (DAT) and immune complex (IMC) methods.

ABO, rhesus blood group, and hemoglobin (Hb) phenotype were determined by using standard technique.

Results: DAT method had a significantly higher rate of detecting sulfadoxine antibodies compared to IMC method (p = 0.019).

Age, gender, and level of education did not affect the prevalence of sulfadoxine antibodies (p > 0.050).

Patients that were an artisan (p < 0.001), married (p = 0.025), living in a two-room apartment (p = 0.003), had history of drug reaction, consumed antimalarial drug (maloxine), and consumed sulfadoxine-containing drug within the last month (p < 0.001 each), and significantly affected the prevalence of sulfadoxine antibodies.

Individuals with Hb phenotype AA had significantly higher prevalence of sulfadoxine antibodies (p < 0.001), and presence of rhesus D antigen was associated with sulfadoxine antibodies.

Conclusions: An overall prevalence of 22.0% among the tested individuals had sulfadoxine antibodies.

Prudent use of sulfadoxine containing drugs is advocated.

American Psychological Association (APA)

Ikuoyogie, Kingsley& Ogefere, Helen Oroboghae& Omoregie, Richard. 2017. Prevalence and risk factors for sulfadoxine antibody among patients undergoing treatment for malaria in Benin City, Nigeria. Oman Medical Journal،Vol. 32, no. 3, pp.207-213.
https://search.emarefa.net/detail/BIM-772340

Modern Language Association (MLA)

Ikuoyogie, Kingsley…[et al.]. Prevalence and risk factors for sulfadoxine antibody among patients undergoing treatment for malaria in Benin City, Nigeria. Oman Medical Journal Vol. 32, no. 3 (May. 2017), pp.207-213.
https://search.emarefa.net/detail/BIM-772340

American Medical Association (AMA)

Ikuoyogie, Kingsley& Ogefere, Helen Oroboghae& Omoregie, Richard. Prevalence and risk factors for sulfadoxine antibody among patients undergoing treatment for malaria in Benin City, Nigeria. Oman Medical Journal. 2017. Vol. 32, no. 3, pp.207-213.
https://search.emarefa.net/detail/BIM-772340

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 213-213

Record ID

BIM-772340