Hyperprolactinemia in reproductive age women presented with abnormal uterine bleeding

Abstract EN

Objective : Abnormal uterine bleeding is a common problem among females of different age groups.

Hyperprolactinemia, which is one of the most common endocrine disorders of hypothalamo-pituitary-ovarian axis, is associated with ovulatory dysfunction that could results in menstrual irregularities.

The aim of this study was to determine the proportion of hyperprolactinemia in reproductive age women with abnormal uterine bleeding.

Methods: A cross-sectional study was conducted in Babylon Teaching Hospital for Gynecology and Pediatrics from December 2013 till November 2014.

The study involved 120 women presented with abnormal uterine bleeding (AUB).

Full assessment was carried out to exclude underlying pathology.

Women with secondary abnormal uterine bleeding were excluded from the study.

Day 2 of cycle hormonal assay was carried out including serum prolactin level.

Results: The percentage of hyperprolactinemia in the total sample was 19 %.

Galactorrhea was found in 69.5 % of women with hypeprolactinemia and in 29% of women with normal prolactin level.

There was significant negative correlation of serum prolactin with Follicular Stimulating Hormone (FSH) (r=-0.260, p=0.004), and Lutenizing Hormone (LH) (r=-0.196, p=0.03).

Conclusions: Hyperprolactinemia is not rare in menstruation related problems in women of reproductive age.

It may or may not be accompanied by galactorrhea, and galactorrhea is not a confirmatory sign for hyperprolactinemia.