Human papillomavirus positive oropharyngeal cancer : the general information

Abstract EN

Oropharyngeal squamous cell cancer (OPSCC) and especially Human papilloma virus positive (HPV+) OPSCC incidence is increasing worldwide over the last decades while the incidence of overall head and neck squamous cancers has declined in developed countries.

HPV + OPSCC has favorable prognosis and is seen in younger patients with lower exposure to tobacco and alcohol.

This review will summarize our current understanding about HPV + OPSCC and clinical differences comparing with HPV OPSCC including current therapy approaches and describe the clinical importance of determining the HPV status.