Pharmacokinetics and bioavailability of thiamphenicol glycinate HCL in male goats
Joint Authors
Source
Kafr El-Sheikh Veterinary Medical Journal
Issue
Vol. 13, Issue 1 (30 Jun. 2015), pp.1-18, 18 p.
Publisher
Kafr El-Sheikh University Faculty of Veterinary Medicine
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The Pharmacokinetic profile of thiamphenicol glycinate HCl was studied in male goats following single intravenous and intramuscular administration of 30 mg kg-1 b.wt.
Thiamphenicol concentration in serum was determined by microbiological assay using Bacillus subtilis (ATCC 6633) as test organism.
After intravenous injection the serum thiamphenicol concentration time course was found to obey two-compartment open model with distribution (t0.5(α)) and elimination (t0.5(β)) half lives of 0.0.06 ± 0.003 and 1.20 + 0.163 h., respectively.
Total body clearance (ClB) and steady state volume of distribution (Vdss) were 1.025 ± 0.04 L kg-1 h-1 and 0.51± 0.010 L kg-1., respectively.
After intramuscular administration the observed mean peak serum concentration (Cmax) was 6.89 ± 0.052 μg ml-1 achieved after maximum time (tmax) of 1.53 ± 0.08 hour post-injection.The systemic bioavailability after intramuscular was 87.61 % .
The plasma protein binding percent was 13.3%.
American Psychological Association (APA)
Bogzil, A. H.& Tohamy, M. A.. 2015. Pharmacokinetics and bioavailability of thiamphenicol glycinate HCL in male goats. Kafr El-Sheikh Veterinary Medical Journal،Vol. 13, no. 1, pp.1-18.
https://search.emarefa.net/detail/BIM-774146
Modern Language Association (MLA)
Bogzil, A. H.& Tohamy, M. A.. Pharmacokinetics and bioavailability of thiamphenicol glycinate HCL in male goats. Kafr El-Sheikh Veterinary Medical Journal Vol. 13, no. 1 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-774146
American Medical Association (AMA)
Bogzil, A. H.& Tohamy, M. A.. Pharmacokinetics and bioavailability of thiamphenicol glycinate HCL in male goats. Kafr El-Sheikh Veterinary Medical Journal. 2015. Vol. 13, no. 1, pp.1-18.
https://search.emarefa.net/detail/BIM-774146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 13-18
Record ID
BIM-774146