Effect of camel milk on diabetic nephropathy in streptozotocin-induced diabetic rats

Abstract EN

Diabetic nephropathy is one of the microvascular complications of diabetes mellitus .

It is a life-threatening complication and occurs in 20-40% of patients suffering from diabetes and it is the single leading cause of end stage renal disease (ESRD) .This present study was designed to explore the efficiency of she camel milk or buffalo milk in controlling diabetic nephropathy .

Eighty male albino rats were used in this study , divided into four groups, one group was used as a normal control group, while the remaining three groups were injected with streptozotocin in order to induce diabetes.

The diabetic group was divided into Diabetic Control Group (DCG), she camel milk group (CMG) and buffalo milk group (BMG),and treated with she camel milk and buffalo milk for 4 weeks.

Blood glucose was measured weekly, microalbuminuria was measured at the 4th week and histopathological study was made at the 1st and the 4th week for measuring the Glomerularsclerosis index .This study revealed that there were a significant decrease in blood glucose of CMG than BMG.

She camel milk group exihibited a significant improvement in microalbuminuria compared to diabetic control animals and ameliorate the patholological changes induced by diabetes.

This study documented the efficiency of she camel milk in controlling of diabetic nephropathy and improvement of kidney function.

the mechanism of this effect is still unknown , so an extensive research on she camel milk is still needed to demonstrate this mechanism