Role of haemodiafiltration in reducing b2-microglobulin and phosphorus in patients with esrd versus conventional haemodialysis

Abstract EN

Online haemodiafiltration (HDF) offers the best rénal replacement therapy (RRT) option for end stage rénal disease (ESRD) patients.

By combining diffusive and convective transfer in the same exchange module, HDF provides the highest clearances of both small and large solutés .

Objective: To assess B2'Microglobulin level in patients undergoing haemodiafiltration compared to those undergoing conventional haemodialysis, To asses the rôle of haemodiafiltration in clearing of phosphorus in patients with ESRD and To introduce a new technique of dialysis in Dialysis Unit of Assiut University Hospital.

Methods: 47 patients with chronic rénal failure on regular hemodialysis for at least six months, ,aged 18-60 years, were classified into two groups: group(A),were 23 patients shifted from conventional HD to post-dilution HDF and group(B),were 24 patients continue their conventional HD rigmen(control group) and the two groups were on 3 sessions/week 4 hours each, rigmen and were subjected to full history and clinical examination ,routine investigations in addition to measurement of sérum B2-Microglohulin and Phosphorus level at the beginning of the study and after six months(the duration of the study) irrespective to the days of HD or HDF.

Results: Our results revealed a significant réduction of /32-Microglobulin after shifting from conventional HD to post-dilution HDF, before HDF was 14.00± 3.07 ug/ml while after HDF was 11.45 ± 2.51ug/ml.

Also, there was also a significant réduction in the phosphorus level after shifting from conventional HD to post-dilution HDF, before HDF was 6.84 ± 1.59 mg/dl while after HDF was 5.36 ± 1.11 mg/dl.Conclusion: Online HDF is an idéal HD technique for reducing B2-microglobulin and phosphorus levels in HD patients.