Impact of thrombophilia on the risk of hypoxic ischemic encephalopathy in term neoxnates
Other Title(s)
تأثير أهبة التخثر على خطر نقص التروية و الأكسجين في المخ في الأطفال حديثي الولادة مكتملي العمر الرحمى
Joint Authors
Abd al-Aziz, Nafisah Hasan Rifat
Munazia, Iman Muhammad M.
Sharif, Tahra
Abd al-Azim, Hanan Jalal
Source
Issue
Vol. 39, Issue 1 (31 Jan. 2015), pp.159-170, 12 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2015-01-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
BACKGROLINÜ The incidence of neonatai hypoxic-ischeinic encephalopatiiy (HIE) is reportediy high iii countries with limited resources.
Its patliogenesis is muitifactorial.
A role for thrombopiiiiia lias becn described in différent patterns of preterm and full terin périnatal brain injury.
AIM OF THE STIJDY; This study aimed to identify risk factors associated with neonatai HIE and also to determine the contributions of genetic thrombophilia in the development of neonatai HIE.
METHODS: Sixty-seven neonates with HIE and 67 Controls were enrolled in the study.
Clinical history and examination were undertaken, Patients and Controls were tested for presence of factor V I.eiden and prothrombin G20210A mutations.
In addition, protein S, protein C and antithrombin III levels were assessed.
RESULTS; Parental consanguinity and performing emergency cesarean section were significant risk factors for neonatai HIE (OR 6.5, 95% Cl 2.6 - 15.3, p < 0.001, OR 12.6, 95% CI 2.52 - 63,3, p = 0.002 respectively).
No significant ditTerencc was found regarding maternai âge and parity.
About 33% of cases and 6% of Controls were found to have at least one thrombophilic factor (p < 0.001).
Factor V i.eiden mutation significantly increased the risk of neonatai HIE (OR 4.5, 95% Cl 1.4 -14.5, p 0.012), w'hile prothrombin G 202 lOA mutation and protein C deficiency were not.
CONCLUSIONS: Parental consanguinity, emergency CS, any thrombophilic factor, particularly factor V mutation may contribute to the higher risk of developing neonatai HIE.
American Psychological Association (APA)
Abd al-Aziz, Nafisah Hasan Rifat& Abd al-Azim, Hanan Jalal& Munazia, Iman Muhammad M.& Sharif, Tahra. 2015. Impact of thrombophilia on the risk of hypoxic ischemic encephalopathy in term neoxnates. Assiut Medical Journal،Vol. 39, no. 1, pp.159-170.
https://search.emarefa.net/detail/BIM-774282
Modern Language Association (MLA)
Abd al-Aziz, Nafisah Hasan Rifat…[et al.]. Impact of thrombophilia on the risk of hypoxic ischemic encephalopathy in term neoxnates. Assiut Medical Journal Vol. 39, no. 1 (Jan. 2015), pp.159-170.
https://search.emarefa.net/detail/BIM-774282
American Medical Association (AMA)
Abd al-Aziz, Nafisah Hasan Rifat& Abd al-Azim, Hanan Jalal& Munazia, Iman Muhammad M.& Sharif, Tahra. Impact of thrombophilia on the risk of hypoxic ischemic encephalopathy in term neoxnates. Assiut Medical Journal. 2015. Vol. 39, no. 1, pp.159-170.
https://search.emarefa.net/detail/BIM-774282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 167-169
Record ID
BIM-774282