Childhood idiopathic steroid-resistant nephrotic syndrome at a single center in Khartoum
Joint Authors
Ali, al-Tigani M. A.
Makki, Hanna F. K.
Allidir, Rashid A.
Abd al-Rahim, Muhammad B.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 4 (31 Aug. 2017), pp.851-859, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-08-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Prevalence, clinicopathological features, and outcome of childhood idiopathic steroid-resistant nephrotic syndrome (ISRNS) vary in different countries.
We report on these parameters in a single center in Khartoum.
We retrospectively reviewed all the records of children with idiopathic nephrotic syndrome (INS) followed up in the pediatric renal unit, Soba Hospital, Khartoum between 2001 and 2012.
ISRNS was defined as no remission within four weeks of daily prednisolone at a dose of 60 mg/m2.
In 430 children with INS 130 (28%) had SRNS with a mean age of 7.7 ± 4.12 years.
Males were 78 (60%).
At presentation, hematuria was recorded in 57%, hypertension was recorded in 48%, and renal impairment in 15%.
Histopathology showed focal segmental glomerulosclerosis in 40.8%, mesangioproliferative glomerulonephritis (22.3%), mesangiocapillary glomerulonephritis (16.9%), minimal change disease (MCD) (16.2%), and membranous glomerulonephritis (3.8%).
Therapy included cyclosporine in 38.5%, additional therapy with cyclophosphamide, mycophenolate mofetil or tacrolimus in 20.8%, and steroids ± diuretics ± angiotensin converting enzyme (ACE) inhibitors in 40.7%.
After 3.64 ± 2.84 years, 26.8% had complete remission (CR), 18.6% partial remission (PR), 26.8% were unremitting, 21.5% had chronic kidney disease (CKD), 1.6% died, and 4.6% were lost to follow-up.
Non- MCD cases had significantly lower CR and higher CKD rates than MCD (P = 0.047 and 0.041, respectively).
Cyclosporine ± additional therapy was significantly associated with higher rate of CR than steroids ± ACE inhibitors ± diuretics (P = 0.001), but the prevalence of CKD between the two groups was not significantly different (P = 0.604).
Impaired renal function and hypertension at presentation were risk factors for CKD (P = 0.001 and 0.001, respectively).
In Sudanese
American Psychological Association (APA)
Ali, al-Tigani M. A.& Makki, Hanna F. K.& Abd al-Rahim, Muhammad B.& Makki, Salwa O.& Allidir, Rashid A.. 2017. Childhood idiopathic steroid-resistant nephrotic syndrome at a single center in Khartoum. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 4, pp.851-859.
https://search.emarefa.net/detail/BIM-776150
Modern Language Association (MLA)
Makki, Salwa O.…[et al.]. Childhood idiopathic steroid-resistant nephrotic syndrome at a single center in Khartoum. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 4 (Jul. / Aug. 2017), pp.851-859.
https://search.emarefa.net/detail/BIM-776150
American Medical Association (AMA)
Ali, al-Tigani M. A.& Makki, Hanna F. K.& Abd al-Rahim, Muhammad B.& Makki, Salwa O.& Allidir, Rashid A.. Childhood idiopathic steroid-resistant nephrotic syndrome at a single center in Khartoum. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 4, pp.851-859.
https://search.emarefa.net/detail/BIM-776150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 857-859
Record ID
BIM-776150