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Dense deposit disease in a child with febrile sore throat
Joint Authors
Conti, Giovanni
Vivo, Dominique De
Vitale, Agata
Fede, Carmelo
Santoro, Domenico
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 4 (31 Aug. 2017), pp.925-928, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-08-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Dense deposit disease or membranoproliferative glomerulonephritis type II is a rare glomerulopathy characterized on renal biopsy by deposition of abnormal electron-dense material in the glomerular basement membrane.
The pathophysiologic basis is uncontrolled systemic activation of the alternate pathway of the complement cascade.
C3 nephritic factor, an autoantibody directed against the C3 convertase of the alternate pathway, plays a key role.
In some patients, complement gene mutations have been identified.
We report the case of a child who had persistent microscopic hematuria, proteinuria, and hypocomplementemia C3 for over 2 months.
Renal biopsy confirmed the diagnosis of dense deposit disease.
American Psychological Association (APA)
Conti, Giovanni& Vivo, Dominique De& Vitale, Agata& Fede, Carmelo& Santoro, Domenico. 2017. Dense deposit disease in a child with febrile sore throat. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 4, pp.925-928.
https://search.emarefa.net/detail/BIM-776221
Modern Language Association (MLA)
Conti, Giovanni…[et al.]. Dense deposit disease in a child with febrile sore throat. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 4 (Jul. / Aug. 2017), pp.925-928.
https://search.emarefa.net/detail/BIM-776221
American Medical Association (AMA)
Conti, Giovanni& Vivo, Dominique De& Vitale, Agata& Fede, Carmelo& Santoro, Domenico. Dense deposit disease in a child with febrile sore throat. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 4, pp.925-928.
https://search.emarefa.net/detail/BIM-776221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 928
Record ID
BIM-776221