Phenolic composition and medicinal usage of Psidium guajava linn : antifungal activity or inhibition of virulence ?

Abstract EN

Psidium guajava is a Myrtaceae plant whose medicinal properties are recognized in several locations.

The use of teas and tinctures prepared from their leaves has been used to combat infections caused by fungi of the genus Candida.

In this study, aqueous extracts of leaves and hydroethanolic were tested to verify the antifungal potential and its chemical composition has been investigated.

The microbiological assays were performed by broth microdilution to determine the minimum inhibitory concentration (MIC) and from these the minimum fungicidal concentration was performed (MFC) by subculturing on solid media.

A cell viability curve was obtained for demonstration of inhibition of fungal growth of strains of Candida albicans and Candida tropicalis.

Tests to check morphological changes by the action of the extracts were performed in microcultive cameras depleted environment at concentrations of MIC/2, MIC and MIC 2.

Extracts analyzed by high performance liquid chromatography demonstrated flavonoids and phenolic acids.

The extracts showed fungistatic effect and no fungicide with MIC >8192 lg/mL, MFC above 8192 lg/mL.

The IC50 was calculated ranging from 1803.02 to 5623.41 lg/mL.

It has been found