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The use of herbs against neglected diseases : evaluation of in vitro leishmanicidal and trypanocidal activity of Stryphnodendron rotundifolium mart
Joint Authors
Coutinho, Henrique D. M.
Menezes, Irwin R. A.
Rolon, Miriam
Vandesmet, Vivianne C. S.
Felipe, Cıcero F. B.
Kerntopf, Marta R.
Vega, Celeste
Coronel, Cathia
Barbosa, Andreza G. R.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 6 (30 Sep. 2017), pp.1136-1141, 6 p.
Publisher
Publication Date
2017-09-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
The evaluation of the leishmanicidal and trypanocidal activity of the hydroalcoholic extract of the bark of Stryphnodendron rotundifolium Mart.
(EHCSR) was carried out to find an alternative treatment for parasitic diseases.
EHCSR was prepared and used at four different concentrations (1000, 500, 250, 125 lg /mL) in in vitro assays for activity against Leishmania promastigotes using the species Leishmania brasiliensis and Leishmania infantum and for trypanocidal activity using the epimastigotes of Trypanosoma cruzi.
We also tested EHCSR for cytotoxicity against adhered cultured Murine J774 fibroblasts.
The tests were performed in triplicate, and the percent mortality of parasites, IC50 and percent toxicity were determined.
With regard to anti-leishmania activity against L.
infantum, there was a mean mortality of 45 % at all concentrations, and against L.
brasiliensis, a substantial effect was seen at 1000 lg / mL with 56.38% mortality, where the IC50 values were 1338.76 and 987.35 lg / mL, respectively.
Trypanocidal activity was notably high at 1000 lg/mL extract with 82.31 % mortality of epimastigotes.
Cytotoxicity at the highest extract concentrations of 500 and 1000 lg / mL was respectively 75.12 % and 94.14 %, with IC50= 190.24 lg / mL.
Despite that the extract has anti-parasitic activity, its substantial cytotoxicity against fibroblasts cells makes its systemic use nonviable as a therapeutic alternative.
American Psychological Association (APA)
Vandesmet, Vivianne C. S.& Felipe, Cıcero F. B.& Kerntopf, Marta R.& Rolon, Miriam& Vega, Celeste& Coronel, Cathia…[et al.]. 2017. The use of herbs against neglected diseases : evaluation of in vitro leishmanicidal and trypanocidal activity of Stryphnodendron rotundifolium mart. Saudi Journal of Biological Sciences،Vol. 24, no. 6, pp.1136-1141.
https://search.emarefa.net/detail/BIM-776433
Modern Language Association (MLA)
Vandesmet, Vivianne C. S.…[et al.]. The use of herbs against neglected diseases : evaluation of in vitro leishmanicidal and trypanocidal activity of Stryphnodendron rotundifolium mart. Saudi Journal of Biological Sciences Vol. 24, no. 6 (Sep. 2017), pp.1136-1141.
https://search.emarefa.net/detail/BIM-776433
American Medical Association (AMA)
Vandesmet, Vivianne C. S.& Felipe, Cıcero F. B.& Kerntopf, Marta R.& Rolon, Miriam& Vega, Celeste& Coronel, Cathia…[et al.]. The use of herbs against neglected diseases : evaluation of in vitro leishmanicidal and trypanocidal activity of Stryphnodendron rotundifolium mart. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 6, pp.1136-1141.
https://search.emarefa.net/detail/BIM-776433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1141
Record ID
BIM-776433